Lipoprotein (a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement

F Kronenberg, S Mora, ESG Stroes… - European heart …, 2022 - academic.oup.com
Abstract This 2022 European Atherosclerosis Society lipoprotein (a)[Lp (a)] consensus
statement updates evidence for the role of Lp (a) in atherosclerotic cardiovascular disease …

Lipoprotein (a): a genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: a scientific statement from the American Heart …

G Reyes-Soffer, HN Ginsberg, L Berglund… - … , and vascular biology, 2022 - Am Heart Assoc
High levels of lipoprotein (a)[Lp (a)], an apoB100-containing lipoprotein, are an independent
and causal risk factor for atherosclerotic cardiovascular diseases through mechanisms …

Single ascending dose study of a short interfering RNA targeting lipoprotein (a) production in individuals with elevated plasma lipoprotein (a) levels

SE Nissen, K Wolski, C Balog, DI Swerdlow… - Jama, 2022 - jamanetwork.com
Importance Lipoprotein (a)(Lp [a]) is an important risk factor for atherothrombotic
cardiovascular disease and aortic stenosis, for which there are no treatments approved by …

Use of Lipoprotein (a) in clinical practice: A biomarker whose time has come. A scientific statement from the National Lipid Association

DP Wilson, TA Jacobson, PH Jones… - Journal of clinical …, 2019 - Elsevier
Abstract Lipoprotein (a)[Lp (a)] is a well-recognized, independent risk factor for
atherosclerotic cardiovascular disease, with elevated levels estimated to be prevalent in …

Statin therapy increases lipoprotein (a) levels

S Tsimikas, PLSM Gordts, C Nora, C Yeang… - European heart …, 2020 - academic.oup.com
Abstract Aims Lipoprotein (a)[Lp (a)] is elevated in 20–30% of people. This study aimed to
assess the effect of statins on Lp (a) levels. Methods and results This subject-level meta …

Lipoprotein (a) and cardiovascular disease

PR Kamstrup - Clinical chemistry, 2021 - academic.oup.com
Background High lipoprotein (a) concentrations present in 10%–20% of the population have
long been linked to increased risk of ischemic cardiovascular disease. It is unclear whether …

A test in context: lipoprotein (a) diagnosis, prognosis, controversies, and emerging therapies

S Tsimikas - Journal of the American College of Cardiology, 2017 - jacc.org
Evidence that elevated lipoprotein (a)(Lp [a]) levels contribute to cardiovascular disease
(CVD) and calcific aortic valve stenosis (CAVS) is substantial. Development of isoform …

NHLBI working group recommendations to reduce lipoprotein (a)-mediated risk of cardiovascular disease and aortic stenosis

S Tsimikas, S Fazio, KC Ferdinand… - Journal of the American …, 2018 - jacc.org
Pathophysiological, epidemiological, and genetic studies provide strong evidence that
lipoprotein (a)[Lp (a)] is a causal mediator of cardiovascular disease (CVD) and calcific …

Calcific aortic stenosis

BR Lindman, MA Clavel, P Mathieu, B Iung… - Nature reviews Disease …, 2016 - nature.com
Calcific aortic stenosis (AS) is the most prevalent heart valve disorder in developed
countries. It is characterized by progressive fibro-calcific remodelling and thickening of the …

Antisense oligonucleotides targeting apolipoprotein (a) in people with raised lipoprotein (a): two randomised, double-blind, placebo-controlled, dose-ranging trials

NJ Viney, JC van Capelleveen, RS Geary, S **a… - The Lancet, 2016 - thelancet.com
Summary Background Elevated lipoprotein (a)(Lp [a]) is a highly prevalent (around 20% of
people) genetic risk factor for cardiovascular disease and calcific aortic valve stenosis, but …