Chronic and recurrent bacterial infections are frequently associated with the formation of
biofilms on biotic or abiotic materials that are composed of mono-or multi-species cultures of …

Acute lung injury (ALI) remains a significant source of morbidity and mortality in the critically
ill patient population. Defined by a constellation of clinical criteria (acute onset of bilateral …

BACKGROUND In the acute respiratory distress syndrome (ARDS), inflammation in the
lungs and other organs can cause life-threatening organ failure. Inhibitors of 3-hydroxy-3 …

Background Statins lower the levels of low-density lipoprotein (LDL) cholesterol and C-
reactive protein (CRP). Whether this latter property affects clinical outcomes is unknown …

Mevalonate pathway is an important metabolic pathway which plays a key role in multiple
cellular processes by synthesizing sterol isoprenoids, such as cholesterol, and non-sterol …

Sepsis is generally viewed as a disease aggravated by an inappropriate immune response
encountered in the afflicted individual. As an important organ system frequently …

Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Myocardial dysfunction is one of the main predictors of poor outcome in septic patients, with
mortality rates next to 70%. During the sepsis-induced myocardial dysfunction, both …

Importance Observational studies have reported that statin use may be associated with
improved outcomes of various infections. Ventilator-associated pneumonia (VAP) is the most …

Background Published data on antiinflammatory and immunomodulatory effects of statins
suggest they may reduce mortality risks associated with an unchecked immune response to …