Mechanosensitive channels: what can they do and how do they do it?

ES Haswell, R Phillips, DC Rees - Structure, 2011 - cell.com
While mechanobiological processes employ diverse mechanisms, at their heart are force-
induced perturbations in the structure and dynamics of molecules capable of triggering …

Bacterial mechanosensors

CD Cox, N Bavi, B Martinac - Annual review of physiology, 2018 - annualreviews.org
Bacteria represent one of the most evolutionarily successful groups of organisms to inhabit
Earth. Their world is awash with mechanical cues, probably the most ancient form of which …

Visualization of the mechanosensitive ion channel MscS under membrane tension

Y Zhang, C Daday, RX Gu, CD Cox, B Martinac… - Nature, 2021 - nature.com
Mechanosensitive channels sense mechanical forces in cell membranes and underlie many
biological sensing processes,–. However, how exactly they sense mechanical force remains …

[LIVRE][B] Chemical reagents for protein modification

RL Lundblad - 2004 - taylorfrancis.com
Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Differential effects of lipids and lyso-lipids on the mechanosensitivity of the mechanosensitive channels MscL and MscS

T Nomura, CG Cranfield, E Deplazes… - Proceedings of the …, 2012 - National Acad Sciences
Mechanosensitive (MS) channels of small (MscS) and large (MscL) conductance are the
major players in the protection of bacterial cells against hypoosmotic shock. Although a …

Mechanosensitive channel gating by delipidation

VJ Flegler, A Rasmussen, K Borbil… - Proceedings of the …, 2021 - National Acad Sciences
The mechanosensitive channel of small conductance (MscS) protects bacteria against
hypoosmotic shock. It can sense the tension in the surrounding membrane and releases …

Molecular force transduction by ion channels–diversity and unifying principles

S Sukharev, F Sachs - Journal of cell science, 2012 - journals.biologists.com
Cells perceive force through a variety of molecular sensors, of which the mechanosensitive
ion channels are the most efficient and act the fastest. These channels apparently evolved to …

MscS-Like10 is a stretch-activated ion channel from Arabidopsis thaliana with a preference for anions

G Maksaev, ES Haswell - Proceedings of the National …, 2012 - National Acad Sciences
Like many other organisms, plants are capable of sensing and responding to mechanical
stimuli such as touch, osmotic pressure, and gravity. One mechanism for the perception of …

Origin of the force: the force-from-lipids principle applied to piezo channels

CD Cox, N Bavi, B Martinac - Current topics in membranes, 2017 - Elsevier
Piezo channels are a ubiquitously expressed, principal type of molecular force sensor in
eukaryotes. They enable cells to decode a myriad of physical stimuli and are essential …

Structural mechanism for gating of a eukaryotic mechanosensitive channel of small conductance

Z Deng, G Maksaev, AM Schlegel, J Zhang… - Nature …, 2020 - nature.com
Mechanosensitive ion channels transduce physical force into electrochemical signaling that
underlies an array of fundamental physiological processes, including hearing, touch …