Cellular redox homeostasis is precisely balanced by generation and elimination of reactive
oxygen species (ROS). ROS are not only capable of causing oxidation of proteins, lipids and …

Nitric oxide (NO) is an important signaling molecule regulating diverse biological processes
in all living organisms. A major physiological function of NO is executed via protein S …

Reversible protein S-nitrosylation regulates a wide range of biological functions and
physiological activities in plants. However, it is challenging to quantitively determine the S …

Cancer immunotherapies targeting immune checkpoints such as programmed cell-death
protein 1 (PD-1) and its ligand programmed cell-death 1 ligand 1 (PD-L1), are …

Introduction: Numerous diseases are caused by changes in post-translational modifications
(PTMs). Therefore, the number of clinical proteomics studies that include the analysis of …

The post-translational modification of cysteine to diverse oxidative states is understood as a
critical cellular mechanism to combat oxidative stress. To study the role of cysteine oxidation …

Oxidative stress is defined as an imbalance between the levels of reactive oxygen species
(ROS) and antioxidant defences. The view of oxidative stress as a cause of cell damage has …

S-nitrosylation is a selective and reversible post-translational modification of protein thiols by
nitric oxide (NO), which is a bioactive signaling molecule, to exert a variety of effects. These …

The reduction of disulfide bonds and their subsequent alkylation are commonplace in typical
proteomics workflows. Here, we highlight a sulfhydryl-reactive alkylating reagent with a …

Many hepatic cytochrome P450 enzymes and their associated drug metabolizing activities
are down-regulated in disease states, and much of this has been associated with …