Calcium ions are ubiquitous and versatile signaling molecules, capable of decoding a
variety of extracellular stimuli (hormones, neurotransmitters, growth factors, etc.) into …

Exocytic and endocytic compartments each have their own unique luminal ion and pH
environment that is important for their normal functioning. A failure to maintain this …

Wave-like propagation of [Ca2+] i increases is a remarkable intercellular communication
characteristic in astrocyte networks, intercalating neural circuits and vasculature …

The Golgi apparatus plays a central role in lipid and protein post-translational modification
and sorting. Morphologically the organelle is heterogeneous and it is possible to distinguish …

The inositol 1, 4, 5-trisphosphate receptor (IP3R) is an intracellular Ca2+ channel that is for
the largest part expressed in the endoplasmic reticulum. Its precise subcellular localization …

Taking advantage of a fluorescent Ca2+ indicator selectively targeted to the trans-Golgi
lumen, we here demonstrate that its Ca2+ homeostatic mechanisms are distinct from those …

Calcium plays an integral role in cellular function. It is a well-recognized second messenger
necessary for signaling cellular responses, but in excessive amounts can be deleterious to …

Accumulation of Ca 2+ into the Golgi apparatus is mediated by sarco (endo) plasmic
reticulum Ca 2+-ATPases (SERCAs) and by secretory pathway Ca 2+-ATPases (SPCAs) …

The Golgi apparatus is a membrane organelle located in the center of the protein processing
and trafficking pathway. It consists of sub-compartments with distinct biochemical …

Recent evidence highlights the functional importance of the Golgi apparatus as an agonist-
sensitive intracellular Ca2+ store. Besides Ca2+-release channels and Ca2+-binding …