PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer
A Glaviano, ASC Foo, HY Lam, KCH Yap, W Jacot… - Molecular cancer, 2023 - Springer
Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …
The progress of novel strategies on immune-based therapy in relapsed or refractory diffuse large B-cell lymphoma
T Lu, J Zhang, ZY Xu-Monette, KH Young - Experimental Hematology & …, 2023 - Springer
Diffuse large B-cell lymphoma (DLBCL) can be cured with standard front-line
immunochemotherapy, whereas nearly 30–40% of patients experience refractory or relapse …
immunochemotherapy, whereas nearly 30–40% of patients experience refractory or relapse …
Targeting autophagy drug discovery: Targets, indications and development trends
M Jiang, W Wu, Z **ong, X Yu, Z Ye, Z Wu - European Journal of Medicinal …, 2024 - Elsevier
Autophagy plays a vital role in sustaining cellular homeostasis and its alterations have been
implicated in the etiology of many diseases. Drugs development targeting autophagy began …
implicated in the etiology of many diseases. Drugs development targeting autophagy began …
Novel agents in relapsed/refractory diffuse large B‐cell lymphoma
G Varma, J Goldstein, RH Advani - Hematological Oncology, 2023 - Wiley Online Library
Patients with relapsed or refractory (R/R) diffuse large B‐cell lymphoma (DLBCL), ineligible
for or relapsing after autologous stem‐cell transplant or chimeric antigen‐receptor T‐cell …
for or relapsing after autologous stem‐cell transplant or chimeric antigen‐receptor T‐cell …
Optimizing treatment for relapsed/refractory classic hodgkin lymphoma in the era of immunotherapy
MP Randall, MA Spinner - Cancers, 2023 - mdpi.com
Simple Summary Classic Hodgkin lymphoma (cHL) has a high cure rate with chemotherapy,
but 10–30% of patients experience relapse or refractory (R/R) disease, depending on stage …
but 10–30% of patients experience relapse or refractory (R/R) disease, depending on stage …
Marine sponge-derived alkaloid inhibits the PI3K/AKT/mTOR signaling pathway against diffuse large B-cell lymphoma
J Liu, YT Chang, YY Kou, PP Zhang, QL Dong… - Medical Oncology, 2024 - Springer
Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous non-Hodgkin
lymphoma that is extremely aggressive and has an intermediate to high malignancy. Some …
lymphoma that is extremely aggressive and has an intermediate to high malignancy. Some …
Molecular classification and therapeutics in diffuse large B-cell lymphoma
G Shimkus, T Nonaka - Frontiers in Molecular Biosciences, 2023 - frontiersin.org
Diffuse large B-cell lymphoma (DLBCL) encompasses a wide variety of disease states that
have to date been subgrouped and characterized based on immunohistochemical methods …
have to date been subgrouped and characterized based on immunohistochemical methods …
Current Status of Novel Agents for the Treatment of B Cell Malignancies: What's Coming Next?
Simple Summary Since the identification of a large variety of biomarkers in B cell
malignancies as being driving factors for tumor progression and patient prognosis, their …
malignancies as being driving factors for tumor progression and patient prognosis, their …
Redefining bioactive small molecules from microbial metabolites as revolutionary anticancer agents
EF Giurini, A Godla, KH Gupta - Cancer Gene Therapy, 2024 - nature.com
Cancer treatment remains a significant challenge due to issues such as acquired resistance
to conventional therapies and the occurrence of adverse treatment-related toxicities. In …
to conventional therapies and the occurrence of adverse treatment-related toxicities. In …
[HTML][HTML] Recent advances in treatment of nodal and gastrointestinal follicular lymphoma
T Watanabe - World Journal of Gastroenterology, 2023 - ncbi.nlm.nih.gov
Follicular lymphoma (FL) is the most common low-grade lymphoma, and although nodal FL
is highly responsive to treatment, the majority of patients relapse repeatedly, and the …
is highly responsive to treatment, the majority of patients relapse repeatedly, and the …