Polysarcosine-containing copolymers: Synthesis, characterization, self-assembly, and applications

A Birke, J Ling, M Barz - Progress in Polymer Science, 2018 - Elsevier
Although the first polysarcosine (pSar) synthesis by Wesseley et al. was reported almost a
century ago, it was only recently that pSar gained broader attention and is considered a …

Secondary structures of synthetic polypeptide polymers

C Bonduelle - Polymer Chemistry, 2018 - pubs.rsc.org
Synthetic peptide-based polymers represent a unique class of macromolecules able to
mimic the properties of natural proteins in materials sciences since (1) they present the …

Multicompartment Polyion Complex Micelles Based on Triblock Polypept (o) ides Mediate Efficient siRNA Delivery to Cancer‐Associated Fibroblasts for Antistromal …

P Schneider, H Zhang, L Simic, Z Dai… - Advanced …, 2024 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the most frequent type of primary liver cancer and the
third leading cause for cancer‐related death worldwide. The tumor is difficult‐to‐treat due to …

Lithium hexamethyldisilazide initiated superfast ring opening polymerization of alpha-amino acid N-carboxyanhydrides

Y Wu, D Zhang, P Ma, R Zhou, L Hua, R Liu - Nature communications, 2018 - nature.com
Polypeptides have broad applications and can be prepared via ring-opening polymerization
of α-amino acid N-carboxyanhydrides (NCAs). Conventional initiators, such as primary …

Solution properties of polysarcosine: from absolute and relative molar mass determinations to complement activation

B Weber, A Birke, K Fischer, M Schmidt, M Barz - Macromolecules, 2018 - ACS Publications
Polysarcosine (pSar) was one of the first polymers synthesized in a controlled living manner,
but it was only recently when it was reconsidered as a promising alternative for poly …

Covalent conjugation of bioactive peptides to graphene oxide for biomedical applications

KE Eckhart, BD Holt, MG Laurencin, SA Sydlik - Biomaterials science, 2019 - pubs.rsc.org
Graphene is a valuable material in biomedical implant applications due to its mechanical
integrity, long-range order, and conductivity; but graphene must be chemically modified to …

Immobilization and Intracellular Delivery of Structurally Nanoengineered Antimicrobial Peptide Polymers Using Polyphenol‐Based Capsules

J Song, C Cortez‐Jugo, SJ Shirbin, Z Lin… - Advanced Functional …, 2022 - Wiley Online Library
Structurally nanoengineered antimicrobial peptide polymers (SNAPPs) are an emerging
class of antimicrobials against multidrug‐resistant bacteria. Their encapsulation in particle …

Modulating antimicrobial activity and mammalian cell biocompatibility with glucosamine-functionalized star polymers

EHH Wong, MM Khin, V Ravikumar, Z Si… - …, 2016 - ACS Publications
The development of novel reagents and antibiotics for combating multidrug resistance
bacteria has received significant attention in recent years. In this study, new antimicrobial …

Peptide-based polymer therapeutics

A Duro-Castano, I Conejos-Sánchez, MJ Vicent - Polymers, 2014 - mdpi.com
Polypeptides are envisaged to achieve a major impact on a number of different relevant
areas such as biomedicine and biotechnology. Acquired knowledge and the increasing …

Increasing bacterial affinity and cytocompatibility with four-arm star glycopolymers and antimicrobial α-polylysine

D Pranantyo, LQ Xu, Z Hou, ET Kang… - Polymer …, 2017 - pubs.rsc.org
A series of four-arm star copolymers, incorporating glycopolymer and antimicrobial
polypeptide domains, was developed in the design of forthcoming anti-infective agents …