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Recombination centres and the orchestration of V (D) J recombination
The initiation of V (D) J recombination by the recombination activating gene 1 (RAG1) and
RAG2 proteins is carefully orchestrated to ensure that antigen receptor gene assembly …
RAG2 proteins is carefully orchestrated to ensure that antigen receptor gene assembly …
V (D) J recombination: mechanisms of initiation
V (D) J recombination assembles immunoglobulin and T cell receptor genes during
lymphocyte development through a series of carefully orchestrated DNA breakage and …
lymphocyte development through a series of carefully orchestrated DNA breakage and …
Global changes in the nuclear positioning of genes and intra-and interdomain genomic interactions that orchestrate B cell fate
The genome is folded into domains located in compartments that are either transcriptionally
inert or transcriptionally permissive. Here we used genome-wide strategies to characterize …
inert or transcriptionally permissive. Here we used genome-wide strategies to characterize …
Epigenetic regulation and T-cell responses in endometriosis–something other than autoimmunity
Endometriosis is defined as the presence of endometrial-like glands and stroma located
outside the uterine cavity. This common, estrogen dependent, inflammatory condition affects …
outside the uterine cavity. This common, estrogen dependent, inflammatory condition affects …
Pax5: a master regulator of B cell development and leukemogenesis
The B cell lineage of the hematopoietic system is responsible for the generation of high-
affinity antibodies, which provide humoral immunity for protection against foreign pathogens …
affinity antibodies, which provide humoral immunity for protection against foreign pathogens …
CTCF-binding elements mediate control of V (D) J recombination
Immunoglobulin heavy chain (IgH) variable region exons are assembled from VH, D and JH
gene segments in develo** B lymphocytes. Within the 2.7-megabase mouse Igh locus, V …
gene segments in develo** B lymphocytes. Within the 2.7-megabase mouse Igh locus, V …
A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation
Cohesin enables post-replicative DNA repair and chromosome segregation by holding
sister chromatids together from the time of DNA replication in S phase until mitosis. There is …
sister chromatids together from the time of DNA replication in S phase until mitosis. There is …
Chromatin insulators: linking genome organization to cellular function
A growing body of evidence suggests that insulators have a primary role in orchestrating the
topological arrangement of higher-order chromatin architecture. Insulator-mediated long …
topological arrangement of higher-order chromatin architecture. Insulator-mediated long …
Epigenetics of haematopoietic cell development
Cells of the immune system are generated through a developmental cascade that begins in
haematopoietic stem cells. During this process, gene expression patterns are programmed …
haematopoietic stem cells. During this process, gene expression patterns are programmed …
Epigenetic control of immunity
M Busslinger, A Tarakhovsky - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Immunity relies on the heterogeneity of immune cells and their ability to respond to pathogen
challenges. In the adaptive immune system, lymphocytes display a highly diverse antigen …
challenges. In the adaptive immune system, lymphocytes display a highly diverse antigen …