Effector CD8+ T cells are typically thought to be a homogenous group of cytotoxic cells that
produce interferon-(IFN) γ. However, recent findings have challenged this notion because …

CD8 T cells play crucial roles in immune surveillance and defense against infections and
cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire …

Although immune checkpoint inhibitors (ICIs) are established as effective cancer therapies,
overcoming therapeutic resistance remains a critical challenge. Here we identify interleukin …

Tertiary lymphoid structures (TLSs) are defined as lymphoid aggregates formed in non-
hematopoietic organs under pathological conditions. Similar to secondary lymphoid organs …

Amino acids are fundamental units of molecular components that are essential for sustaining
life; however, their metabolism is closely interconnected to the control systems of cell …

CD8+ T cell longevity regulated by metabolic activity plays important roles in cancer
immunotherapy. Although in vitro–polarized, transferred IL-9–secreting CD8+ Tc9 (cytotoxic …

Metabolic programming is intricately linked to the anti-tumor properties of T cells. To study
the metabolic pathways associated with increased anti-tumor T cell function, we utilized a …

Not only do Adipocytes have energy storage and endocrine functions, but they also play an
immunological role. Adipocytes are involved in adaptive immunity to mediate the …

Simple Summary Various immune cells are involved in host immune responses to cancer. T-
helper (Th) 1 cells, cytotoxic CD8+ T cells, and natural killer cells are the major effector cells …

Research over the past years has provided increasing understanding about IL‐17‐
producing CD8+ T cells termed Tc17 or IL‐17+ CD8+ T cells, their distribution and role in a …