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Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury
Introduction Ischemia–reperfusion injury (IRI) is the inexplicable aggravation of cellular
dysfunction that results in blood flow restoration to previously ischemic tissues. COX …
dysfunction that results in blood flow restoration to previously ischemic tissues. COX …
Acute spinal cord injury, part I: pathophysiologic mechanisms
RJ Dumont, DO Okonkwo, S Verma… - Clinical …, 2001 - journals.lww.com
Spinal cord injury (SCI) is a devastating and common neurologic disorder that has profound
influences on modern society from physical, psychosocial, and socioeconomic perspectives …
influences on modern society from physical, psychosocial, and socioeconomic perspectives …
Pathophysiology and pharmacologic treatment of acute spinal cord injury
BACKGROUND CONTEXT: The past three decades have witnessed increasing interest in
strategies to improve neurologic function after spinal cord injury. As progress is made in our …
strategies to improve neurologic function after spinal cord injury. As progress is made in our …
Brain neurotrauma: molecular, neuropsychological, and rehabilitation aspects
FH Kobeissy - 2015 - books.google.com
With the contribution from more than one hundred CNS neurotrauma experts, this book
provides a comprehensive and up-to-date account on the latest developments in the area of …
provides a comprehensive and up-to-date account on the latest developments in the area of …
COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
Background While multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) are
primarily inflammatory and degenerative disorders respectively, there is increasing evidence …
primarily inflammatory and degenerative disorders respectively, there is increasing evidence …
Inflammatory processes in amyotrophic lateral sclerosis
Neuroinflammation is a characteristic of pathologically affected tissue in several
neurodegenerative disorders. These changes can be observed in the brainstem and spinal …
neurodegenerative disorders. These changes can be observed in the brainstem and spinal …
Neuroprotection and acute spinal cord injury: a reappraisal
It has long been recognized that much of the post-traumatic degeneration of the spinal cord
following injury is caused by a multi-factorial secondary injury process that occurs during the …
following injury is caused by a multi-factorial secondary injury process that occurs during the …
Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: their role and involvement in neurological disorders
JW Phillis, LA Horrocks, AA Farooqui - Brain research reviews, 2006 - Elsevier
Three enzyme systems, cyclooxygenases that generate prostaglandins, lipoxygenases that
form hydroxy derivatives and leukotrienes, and epoxygenases that give rise to …
form hydroxy derivatives and leukotrienes, and epoxygenases that give rise to …
Recent advances in pathophysiology and treatment of spinal cord injury
CE Hulsebosch - Advances in physiology education, 2002 - journals.physiology.org
Thirty years ago, patients with spinal cord injury (SCI) and their families were told “nothing
can be done” to improve function. Since the SCI patient population is reaching normal life …
can be done” to improve function. Since the SCI patient population is reaching normal life …
Spinal cord contusion models
Publisher Summary This chapter outlines the history and practice of animal spinal cord
contusion models, with particular emphasis on the Multicenter Animal Spinal Cord Injury …
contusion models, with particular emphasis on the Multicenter Animal Spinal Cord Injury …