Chlamydia trachomatis genital infections

CM O'Connell, ME Ferone - Microbial cell, 2016 - pmc.ncbi.nlm.nih.gov
Etiology, transmission and protection: Chlamydia trachomatis is the leading cause of
bacterial sexually transmitted infection (STI) globally. However, C. trachomatis also causes …

Chlamydial plasmid-dependent pathogenicity

G Zhong - Trends in microbiology, 2017 - cell.com
Most Chlamydia species carry a 7.5 kb plasmid encoding eight open reading frames
conventionally called plasmid glycoproteins 1–8 or pGP1–8. Although the plasmid is not …

Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation

M Kessler, K Hoffmann, K Fritsche, V Brinkmann… - Nature …, 2019 - nature.com
Chronic infections of the fallopian tubes with Chlamydia trachomatis (Ctr) cause scarring
and can lead to infertility. Here we use human fallopian tube organoids and genital Ctr …

Recent advances in genetic systems in obligate intracellular human-pathogenic bacteria

DJ Fisher, PA Beare - Frontiers in Cellular and Infection Microbiology, 2023 - frontiersin.org
The ability to genetically manipulate a pathogen is fundamental to discovering factors
governing host–pathogen interactions at the molecular level and is critical for devising …

[HTML][HTML] Psittacosis: an underappreciated and often undiagnosed disease

ZF Dembek, JL Mothershead, AN Owens, T Chekol… - Pathogens, 2023 - mdpi.com
The bacterial agent Chlamydia psittaci, and the resulting disease of psittacosis, is a little-
known and underappreciated infectious disease by healthcare practitioners and in public …

Transformation of Chlamydia muridarum reveals a role for Pgp5 in suppression of plasmid-dependent gene expression

Y Liu, C Chen, S Gong, S Hou, M Qi, Q Liu… - Journal of …, 2014 - journals.asm.org
Transformation of Chlamydia trachomatis should greatly advance the chlamydial research.
However, significant progress has been hindered by the failure of C. trachomatis to induce …

Identification of the alternative sigma factor regulons of Chlamydia trachomatis using multiplexed CRISPR interference

ND Hatch, SP Ouellette - Msphere, 2023 - journals.asm.org
Chlamydia trachomatis is a developmentally regulated, obligate intracellular bacterium that
encodes three sigma factors: σ66, σ54, and σ28. σ66 is the major sigma factor controlling …

A minimal replicon enables efficacious, species-specific gene deletion in Chlamydia and extension of gene knockout studies to the animal model of infection using …

KA Fields, MD Bodero, KR Scanlon… - Infection and …, 2022 - journals.asm.org
The genus Chlamydia consists of diverse, obligate intracellular bacteria that infect various
animals, including humans. Although chlamydial species share many aspects of the typical …

Chlamydia trachomatis and Chlamydia muridarum spectinomycin resistant vectors and a transcriptional fluorescent reporter to monitor conversion from replicative to …

ME Cortina, RJ Ende, RC Bishop, C Bayne, I Derré - PloS one, 2019 - journals.plos.org
Chlamydia trachomatis infections are the leading cause of sexually transmitted infections of
bacterial origin. Lower genital tract infections are often asymptomatic, and therefore left …

Molecular Genetic Analysis of Chlamydia Species

BS Sixt, RH Valdivia - Annual Review of Microbiology, 2016 - annualreviews.org
Species of Chlamydia are the etiologic agent of endemic blinding trachoma, the leading
cause of bacterial sexually transmitted diseases, significant respiratory pathogens, and a …