Schizophrenia—an overview
Importance Schizophrenia is a common, severe mental illness that most clinicians will
encounter regularly during their practice. This report provides an overview of the clinical …
encounter regularly during their practice. This report provides an overview of the clinical …
The neurobiology of treatment-resistant schizophrenia: paths to antipsychotic resistance and a roadmap for future research
SG Potkin, JM Kane, CU Correll, JP Lindenmayer… - NPJ …, 2020 - nature.com
Abstract Treatment-resistant schizophrenia (TRS), the persistence of positive symptoms
despite≥ 2 trials of adequate dose and duration of antipsychotic medication with …
despite≥ 2 trials of adequate dose and duration of antipsychotic medication with …
Dopamine and glutamate in schizophrenia: biology, symptoms and treatment
Glutamate and dopamine systems play distinct roles in terms of neuronal signalling, yet both
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
have been proposed to contribute significantly to the pathophysiology of schizophrenia. In …
Economics and mental health: the current scenario
Economics and mental health are intertwined. Apart from the accumulating evidence of the
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
huge economic impacts of mental ill‐health, and the growing recognition of the effects that …
A guideline and checklist for initiating and managing clozapine treatment in patients with treatment-resistant schizophrenia
Abstract Treatment-resistant schizophrenia (TRS) will affect about one in three patients with
schizophrenia. Clozapine is the only treatment approved for TRS, and patients should be …
schizophrenia. Clozapine is the only treatment approved for TRS, and patients should be …
Two distinct neuroanatomical subtypes of schizophrenia revealed using machine learning
Neurobiological heterogeneity in schizophrenia is poorly understood and confounds current
analyses. We investigated neuroanatomical subtypes in a multi-institutional multi-ethnic …
analyses. We investigated neuroanatomical subtypes in a multi-institutional multi-ethnic …
[HTML][HTML] Clinical guidance on the identification and management of treatment-resistant schizophrenia
JM Kane, O Agid, ML Baldwin… - The Journal of …, 2019 - legacy.psychiatrist.com
Treatment-resistant schizophrenia (TRS) occurs in approximately 30% of individuals
diagnosed with schizophrenia. The identification and management of TRS in clinical …
diagnosed with schizophrenia. The identification and management of TRS in clinical …
Guidelines for the pharmacotherapy of schizophrenia in adults
G Remington, D Addington, W Honer… - The Canadian …, 2017 - journals.sagepub.com
Objective: The present guidelines address the pharmacotherapy of schizophrenia in adults
across different stages, phases, and symptom domains. Method: Guidelines were developed …
across different stages, phases, and symptom domains. Method: Guidelines were developed …
Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but
this has not been tested directly in vivo. Here, we investigated synaptic vesicle glycoprotein …
this has not been tested directly in vivo. Here, we investigated synaptic vesicle glycoprotein …
[HTML][HTML] Cognitive dysfunction in schizophrenia: an expert group paper on the current state of the art
Cognitive impairment in schizophrenia represents one of the main obstacles to clinical and
functional recovery. This expert group paper brings together experts in schizophrenia …
functional recovery. This expert group paper brings together experts in schizophrenia …