Intercellular receptor-ligand binding: effect of protein-membrane interaction

L Li, J Ji, F Song, J Hu - Journal of Molecular Biology, 2023 - Elsevier
Gaining insights into the intercellular receptor-ligand binding is of great importance for
understanding numerous physiological and pathological processes, and stimulating new …

Receptor–Ligand Binding: Effect of Mechanical Factors

R Du, L Li, J Ji, Y Fan - International Journal of Molecular Sciences, 2023 - mdpi.com
Gaining insight into the in situ receptor–ligand binding is pivotal for revealing the molecular
mechanisms underlying the physiological and pathological processes and will contribute to …

Capturing phase behavior of ternary lipid mixtures with a refined martini coarse-grained force field

TS Carpenter, CA López, C Neale… - Journal of chemical …, 2018 - ACS Publications
Whether lipid rafts are present in the membranes of living cells remains hotly disputed
despite their incontrovertible existence in liposomes at 298 K. In attempts to resolve this …

Interplay between cooperativity of intercellular receptor–ligand binding and coalescence of nanoscale lipid clusters in adhering membranes

L Li, J Hu, X Shi, B Różycki, F Song - Soft Matter, 2021 - pubs.rsc.org
Adhesion of biological cells is mediated by the specific binding of receptors and ligands
which are typically large proteins spanning through the plasma membranes of the contacting …

Modelling lipid rafts formation through chemo-mechanical interplay triggered by receptor–ligand binding

C Bernard, AR Carotenuto, NM Pugno, M Fraldi… - … and Modeling in …, 2024 - Springer
Cell membranes, mediator of many biological mechanisms from adhesion and metabolism
up to mutation and infection, are highly dynamic and heterogeneous environments …

Membrane-Mediated Cooperative Interactions of CD47 and SIRPα

L Li, C Gui, J Hu, B Różycki - Membranes, 2023 - mdpi.com
The specific binding of the ubiquitous 'marker of self'protein CD47 to the SIRP α protein
anchored in the macrophage plasma membrane results in the inhibition of the engulfment of …

Interplay between receptor-ligand binding and lipid domain formation depends on the mobility of ligands in cell-substrate adhesion

L Li, X Wang, H Wu, Y Shao, H Wu… - Frontiers in Molecular …, 2021 - frontiersin.org
Cell-cell adhesion and the adhesion of cells to extracellular matrix are mediated by the
specific binding of receptors on the cell membrane to their cognate ligands on the opposing …

Intercellular receptor–ligand binding and thermal fluctuations facilitate receptor aggregation in adhering membranes

L Li, J Hu, B Różycki, F Song - Nano letters, 2019 - ACS Publications
Nanoscale molecular clusters in cell membranes can serve as platforms to recruit
membrane proteins for various biological functions. A central question is how these …

Interplay of receptor-ligand binding and lipid domain formation during cell adhesion

L Li, J Hu, B Różycki, J Ji, F Song - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Cell adhesion involved in biological processes such as cell migration, immune responses,
and cancer metastasis, is mediated by the specific binding of receptor and ligand proteins …

Mechanobiology predicts raft formations triggered by ligand-receptor activity across the cell membrane

AR Carotenuto, L Lunghi, V Piccolo, M Babaei… - Journal of the …, 2020 - Elsevier
Clustering of ligand-binding receptors of different types on thickened isles of the cell
membrane, namely lipid rafts, is an experimentally observed phenomenon. Although its …