Inteins as drug targets and therapeutic tools
Multidrug-resistant pathogens are of significant concern in recent years. Hence new
antifungal and anti-bacterial drug targets are urgently needed before the situation goes …
antifungal and anti-bacterial drug targets are urgently needed before the situation goes …
Inteins: A Swiss army knife for synthetic biology
Inteins are proteins found in nature that execute protein splicing. Among them, split inteins
stand out for their versatility and adaptability, presenting creative solutions for addressing …
stand out for their versatility and adaptability, presenting creative solutions for addressing …
Metal regulation of Mycobacterium tuberculosis SufB intein splicing at the host–pathogen crossroad
Intein sequences self-excise from precursor proteins to generate functional proteins in
various organisms. Thus, regulation of intein splicing at the host–pathogen interface can …
various organisms. Thus, regulation of intein splicing at the host–pathogen interface can …
Intein inhibitors as novel antimicrobials: protein splicing in human pathogens, screening methods, and off-target considerations
Protein splicing is a post-translational process by which an intervening polypeptide, or
intein, catalyzes its own removal from the flanking polypeptides, or exteins, concomitant with …
intein, catalyzes its own removal from the flanking polypeptides, or exteins, concomitant with …
Calcimycin Inhibits Cryptococcus neoformans In Vitro and In Vivo by Targeting the Prp8 Intein Splicing
Drug resistance is a significant concern in the treatment of diseases, including
cryptococcosis caused by Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga) …
cryptococcosis caused by Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga) …
SufB intein splicing in Mycobacterium tuberculosis is influenced by two remote conserved N-extein histidines
Inteins are auto-processing domains that implement a multistep biochemical reaction termed
protein splicing, marked by cleavage and formation of peptide bonds. They excise from a …
protein splicing, marked by cleavage and formation of peptide bonds. They excise from a …
Molecular docking and MD simulations reveal protease inhibitors block the catalytic residues in Prp8 intein of Aspergillus fumigatus: a potential target for antimycotics
Resistance to azoles and amphotericin B especially in Aspergillus fumigatus is a growing
concern towards the treatment of invasive fungal infection. At this critical juncture, intein …
concern towards the treatment of invasive fungal infection. At this critical juncture, intein …
Conditional protein splicing triggered by SUMO protease
M Xu, S Wang, Q Zhan, Y Lin - Biochemical and Biophysical Research …, 2023 - Elsevier
Conditional protein splicing is a powerful biotechnological tool that can be used to post-
translationally control the activity of target proteins. Here we demonstrated a novel …
translationally control the activity of target proteins. Here we demonstrated a novel …
Cleaving the way for heterologous peptide production: An overview of cleavage strategies
KO Osiro, HM Duque, KBS de Oliveira, NTM Melo… - Methods, 2024 - Elsevier
One of the main bottlenecks for recombinant peptide production is choosing the proper
cleavage method to remove fusion protein tags from target peptides. While these tags are …
cleavage method to remove fusion protein tags from target peptides. While these tags are …
Characteristics, Recombination Methods, and Applications Progresses of Split-Cas9 System
Z Liu, L Huang, H Deng, Y Chen, H **ao - Human Gene Therapy, 2023 - liebertpub.com
CRISPR technology has been used to revolutionize various facets of life sciences because
of its potent gene editing capabilities. In particular, CRISPR technology is anticipated to be …
of its potent gene editing capabilities. In particular, CRISPR technology is anticipated to be …