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Oxyradicals and DNA damage
LJ Marnett - carcinogenesis, 2000 - academic.oup.com
A major development of carcinogenesis research in the past 20 years has been the
discovery of significant levels of DNA damage arising from endogenous cellular sources …
discovery of significant levels of DNA damage arising from endogenous cellular sources …
Endogenous DNA damage in humans: a review of quantitative data
R De Bont, N Van Larebeke - Mutagenesis, 2004 - academic.oup.com
DNA damage plays a major role in mutagenesis, carcinogenesis and ageing. The vast
majority of mutations in human tissues are certainly of endogenous origin. A thorough …
majority of mutations in human tissues are certainly of endogenous origin. A thorough …
Oxidative DNA damage and disease: induction, repair and significance
The generation of reactive oxygen species may be both beneficial to cells, performing a
function in inter-and intracellular signalling, and detrimental, modifying cellular …
function in inter-and intracellular signalling, and detrimental, modifying cellular …
Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis
H Kasai - Mutation Research/Reviews in Mutation Research, 1997 - Elsevier
8-hydroxy-2′-deoxyguanosine (8-OH-dG) was first reported in 1984 as a major form of
oxidative DNA damage product by heated sugar, Fenton-type reagents and X-irradiation in …
oxidative DNA damage product by heated sugar, Fenton-type reagents and X-irradiation in …
[کتاب][B] Free-radical-induced DNA damage and its repair
C von Sonntag - 2006 - Springer
When talking about research, I must mention Mrs. Rita Wagner, a superb technician that
looked after my laboratory and the younger Ph. D. students for about 25 years. Some of her …
looked after my laboratory and the younger Ph. D. students for about 25 years. Some of her …
Role of oxygen free radicals in cancer development
D Dreher, AF Junod - European Journal of cancer, 1996 - Elsevier
In aerobic life, oxidative stress arises from both endogenous and exogenous sources.
Despite antioxidant defence mechanisms, cell damage from oxygen free radicals (OFR) is …
Despite antioxidant defence mechanisms, cell damage from oxygen free radicals (OFR) is …
Reactions of oxyl radicals with DNA
The importance of radical-induced damage to DNA is apparent from the ever-increasing
number of publications in this area. This review focuses on the damage caused to DNA by …
number of publications in this area. This review focuses on the damage caused to DNA by …
DNA replication fidelity
TA Kunkel, K Bebenek - Annual review of biochemistry, 2000 - annualreviews.org
▪ Abstract DNA replication fidelity is a key determinant of genome stability and is central to
the evolution of species and to the origins of human diseases. Here we review our current …
the evolution of species and to the origins of human diseases. Here we review our current …
The contribution of endogenous sources of DNA damage to the multiple mutations in cancer
There is increasing evidence that most human cancers contain multiple mutations. By the
time a tumor is clinically detectable it may have accumulated tens of thousands of mutations …
time a tumor is clinically detectable it may have accumulated tens of thousands of mutations …
Oxidatively induced DNA damage and its repair in cancer
Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …