The intestinal barrier protects the host against gut microbes, food antigens, and toxins
present in the gastrointestinal tract. However, gut barrier integrity can be affected by intrinsic …

Metabolic disorders represent a growing worldwide health challenge due to their
dramatically increasing prevalence. The gut microbiota is a crucial actor that can interact …

The gut microbiota is responsible for recovering energy from food, providing hosts with
vitamins, and providing a barrier function against exogenous pathogens. In addition, it is …

The human gastrointestinal tract (GI) harbors a diverse population of microbial life that
continually shapes host pathophysiological responses. Despite readily available abundant …

Tight junctions (TJs) play an important role in intestinal barrier function. TJs in intestinal
epithelial cells are composed of different junctional molecules, such as claudin and …

The intestinal tract is the largest barrier between a person and the environment. In this role,
the intestinal tract is responsible not only for absorbing essential dietary nutrients, but also …

It is well established that bile acids play important roles in lipid metabolism. In recent
decades, bile acids have also been shown to function as signaling molecules via interacting …

Although disrupted bile acid (BA) homeostasis is implicated in inflammatory bowel disease
(IBD), the role of hepatic BA metabolism in the pathogenesis of colitis is poorly understood …

The intestine is the largest peripheral lymphoid organ in animals, including humans, and
interacts with a vast array of microorganisms called the gut microbiota. Comprehending the …

Overweight and obesity are associated with several cardiometabolic risk factors, including
insulin resistance, type 2 diabetes, low-grade inflammation and liver diseases. The gut …