Cancers Complicating Inflammatory Bowel Disease | New England Journal of Medicine Skip to
main content The New England Journal of Medicine homepage Advanced Search SEARCH …

Mutational processes that alter large genomic regions occur frequently in develo**
tumors. They range from simple copy number gains and losses to the shattering and …

With ageing, normal human tissues experience an expansion of somatic clones that carry
cancer mutations,,,,,–. However, whether such clonal expansion exists in the non-neoplastic …

Inflammation is emerging as one of the hallmarks of cancer, yet its role in most tumors
remains unclear. Whereas a minority of solid tumors are associated with overt inflammation …

Patients with ulcerative colitis and Crohn's disease are at increased risk for develo**
colorectal cancer (CRC). Chronic inflammation is believed to promote carcinogenesis. The …

Background Colorectal cancer (CRC) is one of the leading cause of cancer deaths
worldwide. Since CRC is largely asymptomatic until alarm features develop to advanced …

Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory
component is present also in the microenvironment of tumors that are not epidemiologically …

The tumor suppressor p53 is frequently mutated in human cancer. Common mutant p53
(mutp53) isoforms can actively promote cancer through gain-of-function (GOF) mechanisms …

One of the most important consequences of chronically active ulcerative colitis (UC) or
Crohn's disease (CD)–the two major forms of inflammatory bowel disease (IBD)–is the …

The cumulative impact of chronic inflammation in patients with inflammatory bowel diseases
predisposes to the development of inflammatory bowel disease-associated colorectal …