Survey of the Aβ-peptide structural diversity: molecular dynamics approaches
AP Tolstova, AA Adzhubei, MA Strelkova… - Biophysical …, 2024 - Springer
The review deals with the application of Molecular Dynamics (MD) to the structure modeling
of beta-amyloids (Aβ), currently classified as intrinsically disordered proteins (IDPs). In this …
of beta-amyloids (Aβ), currently classified as intrinsically disordered proteins (IDPs). In this …
[HTML][HTML] Proteomic evidence for amyloidogenic cross-seeding in fibrinaloid microclots
In classical amyloidoses, amyloid fibres form through the nucleation and accretion of protein
monomers, with protofibrils and fibrils exhibiting a cross-β motif of parallel or antiparallel β …
monomers, with protofibrils and fibrils exhibiting a cross-β motif of parallel or antiparallel β …
Structural Insight into Melatonin's Influence on the Conformation of Aβ42 Dimer Studied by Molecular Dynamics Simulation
W Kang, Y Lu, JC Etaka, FR Salsbury Jr… - The Journal of …, 2024 - ACS Publications
The accumulation of amyloid-beta (Aβ) oligomers is recognized as a potential culprit in
Alzheimer's disease (AD). Experimental studies show that melatonin, a hormone that mainly …
Alzheimer's disease (AD). Experimental studies show that melatonin, a hormone that mainly …
Unravelling the Complexity of Amyloid Peptide Core Interfaces
Amyloids, large intermolecular sandwiched β-sheet structures, underlie several protein
misfolding diseases but have also been shown to have functional roles and can be a basis …
misfolding diseases but have also been shown to have functional roles and can be a basis …
Coarse-Grained Simulation Study of the Association of Selected Dipeptides
The association of 55 dipeptides extracted from aggregation-prone regions of selected
proteins was studied by means of multiplexed replica-exchange molecular dynamics …
proteins was studied by means of multiplexed replica-exchange molecular dynamics …
The energy landscape of Aβ 42: a funnel to disorder for the monomer becomes a folding funnel for self-assembly
The aggregation of amyloid-β (Aβ) peptides, particularly Aβ1–42, plays a key role in
Alzheimer's disease pathogenesis. In this study, we investigate how dimerisation transforms …
Alzheimer's disease pathogenesis. In this study, we investigate how dimerisation transforms …