Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in
endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is …

Membrane trafficking between organelles by vesiculotubular carriers is fundamental to the
existence of eukaryotic cells. Central in ensuring that cargoes are delivered to their correct …

Guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs)
regulate the activity of small guanine nucleotide-binding (G) proteins to control cellular …

Endocytosis entails selective packaging of cell-surface proteins, such as receptors for
cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of …

Extensive research on the Ras proteins and their functions in cell physiology over the past
30 years has led to numerous insights that have revealed the involvement of Ras not only in …

The epidermal growth factor receptor (EGFR) signaling pathway is one of the most important
pathways that regulate growth, survival, proliferation, and differentiation in mammalian cells …

The tumor oncoproteins HRAS, KRAS, and NRAS are the founding members of a larger
family of at least 35 related human proteins. Using a somewhat broader definition of …

Ras signalling has classically been thought to occur exclusively at the inner surface of a
relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact …

RAS proteins are small GTPases, which serve as master regulators of a myriad of signaling
cascades involved in highly diverse cellular processes. RAS oncogenes have been …

Binding of hormones, growth factors and other cell modulators to cell-surface receptors
triggers a complex array of signal-transduction events. The activation of many receptors also …