Old drugs as new treatments for neurodegenerative diseases

F Durães, M Pinto, E Sousa - Pharmaceuticals, 2018 - mdpi.com
Neurodegenerative diseases are increasing in number, given that the general global
population is becoming older. They manifest themselves through mechanisms that are not …

Recommendations for the diagnosis and management of Alzheimer's disease and other disorders associated with dementia: EFNS guideline

G Waldemar, B Dubois, M Emre… - European Journal of …, 2007 - Wiley Online Library
The aim of this international guideline on dementia was to present a peer‐reviewed
evidence‐based statement for the guidance of practice for clinical neurologists, geriatricians …

Interleukin-6, C-reactive protein and interleukin-10 after antidepressant treatment in people with depression: a meta-analysis

SA Hiles, AL Baker, T de Malmanche… - Psychological medicine, 2012 - cambridge.org
BackgroundCross-sectional studies support an association between depression and
inflammatory markers. However, little is known of their relationship in the context of …

Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease

IJ Martins, T Berger, MJ Sharman… - Journal of …, 2009 - Wiley Online Library
Alzheimer's disease (AD) is the most common neurodegenerative disorder, affecting millions
of people worldwide. Apart from age, the major risk factor identified so far for the sporadic …

Therapeutic drug repositioning with special emphasis on neurodegenerative diseases: Threats and issues

BB Kakoti, R Bezbaruah, N Ahmed - Frontiers in Pharmacology, 2022 - frontiersin.org
Drug repositioning or repurposing is the process of discovering leading-edge indications for
authorized or declined/abandoned molecules for use in different diseases. This approach …

Altered cholesterol homeostasis in Huntington's disease

R Kacher, C Mounier, J Caboche… - Frontiers in aging …, 2022 - frontiersin.org
Huntington's disease (HD) is an autosomal dominant genetic disorder caused by an
expansion of the CAG repeat in the first exon of Huntingtin's gene. The associated …

Exploring the efficacy of natural products in alleviating Alzheimer's disease

P Deshpande, N Gogia, A Singh - Neural regeneration research, 2019 - journals.lww.com
Alzheimer's disease (hereafter AD) is a progressive neurodegenerative disorder that affects
the central nervous system. There are multiple factors that cause AD, viz., accumulation of …

Reduced risk of incident AD with elective statin use in a clinical trial cohort

DL Sparks, RJ Kryscio, MN Sabbagh… - Current Alzheimer …, 2008 - ingentaconnect.com
Statins have been reported to reduce the risk and be of benefit in the treatment of
Alzheimer's disease (AD). Individuals enrolling in the randomized controlled trial testing two …

Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis

CJ Carter - Neurochemistry international, 2007 - Elsevier
Polymorphic genes associated with Alzheimer's disease (see) delineate a clearly defined
pathway related to cerebral and peripheral cholesterol and lipoprotein homoeostasis. They …

Disease modifying therapy for AD?1

TE Golde - Journal of neurochemistry, 2006 - Wiley Online Library
Alzheimer's disease (AD) is the most common form of dementia in industrialized nations. If
more effective therapies are not developed that either prevent AD or block progression of the …