DNA synthesis technologies to close the gene writing gap
Synthetic DNA is of increasing demand across many sectors of research and commercial
activities. Engineering biology, therapy, data storage and nanotechnology are set for rapid …
activities. Engineering biology, therapy, data storage and nanotechnology are set for rapid …
Chemistries for DNA nanotechnology
M Madsen, KV Gothelf - Chemical reviews, 2019 - ACS Publications
The predictable nature of DNA interactions enables the programmable assembly of highly
advanced 2D and 3D DNA structures of nanoscale dimensions. The access to ever larger …
advanced 2D and 3D DNA structures of nanoscale dimensions. The access to ever larger …
Genetic alphabet expansion technology by creating unnatural base pairs
Recent advancements in the creation of artificial extra base pairs (unnatural base pairs,
UBPs) are opening the door to a new research area, xenobiology, and genetic alphabet …
UBPs) are opening the door to a new research area, xenobiology, and genetic alphabet …
Chemical modification of aptamers for increased binding affinity in diagnostic applications: Current status and future prospects
JP Elskens, JM Elskens, A Madder - International journal of molecular …, 2020 - mdpi.com
Aptamers are short single stranded DNA or RNA oligonucleotides that can recognize
analytes with extraordinary target selectivity and affinity. Despite their promising properties …
analytes with extraordinary target selectivity and affinity. Despite their promising properties …
From DNA nanotechnology to material systems engineering
Y Hu, CM Niemeyer - Advanced Materials, 2019 - Wiley Online Library
In the past 35 years, DNA nanotechnology has grown to a highly innovative and vibrant field
of research at the interface of chemistry, materials science, biotechnology, and …
of research at the interface of chemistry, materials science, biotechnology, and …
Modified nucleic acids: Expanding the capabilities of functional oligonucleotides
In the last three decades, oligonucleotides have been extensively investigated as probes,
molecular ligands and even catalysts within therapeutic and diagnostic applications. The …
molecular ligands and even catalysts within therapeutic and diagnostic applications. The …
Geared toward applications: A perspective on functional sequence-controlled polymers
Sequence-controlled polymers are an emerging class of synthetic polymers with a regulated
sequence of monomers. In the past decade, tremendous progress has been made in the …
sequence of monomers. In the past decade, tremendous progress has been made in the …
Simple methods and rational design for enhancing aptamer sensitivity and specificity
P Kalra, A Dhiman, WC Cho, JG Bruno… - Frontiers in molecular …, 2018 - frontiersin.org
Aptamers are structured nucleic acid molecules that can bind to their targets with high affinity
and specificity. However, conventional SELEX (Systematic Evolution of Ligands by …
and specificity. However, conventional SELEX (Systematic Evolution of Ligands by …
The structural diversity of artificial genetic polymers
Synthetic genetics is a subdiscipline of synthetic biology that aims to develop artificial
genetic polymers (also referred to as xeno-nucleic acids or XNAs) that can replicate in vitro …
genetic polymers (also referred to as xeno-nucleic acids or XNAs) that can replicate in vitro …
DNA polymerases divide the labor of genome replication
SA Lujan, JS Williams, TA Kunkel - Trends in cell biology, 2016 - cell.com
DNA polymerases synthesize DNA in only one direction, but large genomes require RNA
priming and bidirectional replication from internal origins. We review here the physical …
priming and bidirectional replication from internal origins. We review here the physical …