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Control of stem cell renewal and fate by YAP and TAZ
JH Driskill, D Pan - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Complex physiological processes control whether stem cells self-renew, differentiate or
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …
remain quiescent. Two decades of research have placed the Hippo pathway, a highly …
Mechanical regulation of chromatin and transcription
S Dupont, SA Wickström - Nature Reviews Genetics, 2022 - nature.com
Cells and tissues generate and are exposed to various mechanical forces that act across a
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …
range of scales, from tissues to cells to organelles. Forces provide crucial signals to inform …
Modelling human blastocysts by reprogramming fibroblasts into iBlastoids
X Liu, JP Tan, J Schröder, A Aberkane, JF Ouyang… - Nature, 2021 - nature.com
Human pluripotent and trophoblast stem cells have been essential alternatives to
blastocysts for understanding early human development,,–. However, these simple culture …
blastocysts for understanding early human development,,–. However, these simple culture …
Hippo–YAP/TAZ signalling in organ regeneration and regenerative medicine
The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) …
Derivation of trophoblast stem cells from naïve human pluripotent stem cells
Naïve human pluripotent stem cells (hPSCs) provide a unique experimental platform of cell
fate decisions during pre-implantation development, but their lineage potential remains …
fate decisions during pre-implantation development, but their lineage potential remains …
Hallmarks of totipotent and pluripotent stem cell states
Though totipotency and pluripotency are transient during early embryogenesis, they
establish the foundation for the development of all mammals. Studying these in vivo has …
establish the foundation for the development of all mammals. Studying these in vivo has …
[HTML][HTML] Regulation of TEAD transcription factors in cancer biology
Transcriptional enhanced associate domain (TEAD) transcription factors play important roles
during development, cell proliferation, regeneration, and tissue homeostasis. TEAD …
during development, cell proliferation, regeneration, and tissue homeostasis. TEAD …
Naive human embryonic stem cells can give rise to cells with a trophoblast-like transcriptome and methylome
JK Cinkornpumin, SY Kwon, Y Guo, I Hossain, J Sirois… - Stem cell reports, 2020 - cell.com
Human embryonic stem cells (hESCs) readily differentiate to somatic or germ lineages but
have impaired ability to form extra-embryonic lineages such as placenta or yolk sac. Here …
have impaired ability to form extra-embryonic lineages such as placenta or yolk sac. Here …
Mechanisms of human embryo development: from cell fate to tissue shape and back
MN Shahbazi - Development, 2020 - journals.biologists.com
Gene regulatory networks and tissue morphogenetic events drive the emergence of shape
and function: the pillars of embryo development. Although model systems offer a window …
and function: the pillars of embryo development. Although model systems offer a window …
Highly cooperative chimeric super-SOX induces naive pluripotency across species
CM MacCarthy, G Wu, V Malik, Y Menuchin-Lasowski… - Cell Stem Cell, 2024 - cell.com
Our understanding of pluripotency remains limited: iPSC generation has only been
established for a few model species, pluripotent stem cell lines exhibit inconsistent …
established for a few model species, pluripotent stem cell lines exhibit inconsistent …