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Robust acquisition of spatial transcriptional programs in tissues with immunofluorescence-guided laser capture microdissection
The functioning of tissues is fundamentally dependent upon not only the phenotypes of the
constituent cells but also their spatial organization in the tissue, as local interactions …
constituent cells but also their spatial organization in the tissue, as local interactions …
Highly multiplexed oligonucleotide probe-ligation testing enables efficient extraction-free SARS-CoV-2 detection and viral genoty**
There is an urgent and unprecedented need for sensitive and high-throughput molecular
diagnostic tests to combat the SARS-CoV-2 pandemic. Here we present a generalized …
diagnostic tests to combat the SARS-CoV-2 pandemic. Here we present a generalized …
Pancreatic cancer driver mutations are targetable through distant alternative RNA splicing dependencies
Pancreatic ductal adenocarcinoma (PDAC), the most common histological subtype of
pancreatic cancer, has one of the highest case fatality rates of all known solid malignancies …
pancreatic cancer, has one of the highest case fatality rates of all known solid malignancies …
Fluid delivery methods
H Kim, AM Tentori, S **ng, R Bharadwaj… - US Patent …, 2024 - Google Patents
Provided herein is a fluid delivery method for permeabilizing a biological sample. The
method includes delivering the fluid to a first substrate and/or a second substrate. At least …
method includes delivering the fluid to a first substrate and/or a second substrate. At least …
Dual Probe Ligation In Situ Hybridization with Rolling-Circle Amplification for High-Plex Spatial Transcriptomics
S Maguire, J Credle, E Bertelson, S Lee, B Cha, D **e… - bioRxiv, 2025 - biorxiv.org
New biological insights are increasingly dependent upon a deeper understanding of tissue
architectures. Critical to such studies are spatial transcriptomics technologies, especially …
architectures. Critical to such studies are spatial transcriptomics technologies, especially …
Robust acquisition of high resolution spatial transcriptomes from preserved tissues with immunofluorescence based laser capture microdissection
X Zhang, C Hu, C Huang, Y Wei, X Li, M Hu, H Li, J Wu… - bioRxiv, 2021 - biorxiv.org
The functioning of tissues is fundamentally dependent upon not only the phenotypes of the
constituent cells but also their spatial organization in the tissue. However, obtaining …
constituent cells but also their spatial organization in the tissue. However, obtaining …
In situ rna analysis using probe pair ligation
H Larman, J Credie - US Patent App. 17/790,293, 2023 - Google Patents
The present invention relates to the field of ribonucleotide analysis. More specifically, the
present invention provides compositions and methods for detection for nucleic acids using …
present invention provides compositions and methods for detection for nucleic acids using …
Beyond the microscope: interpreting renal biopsy findings in the era of precision medicine
SM Bagnasco - American Journal of Physiology-Renal …, 2018 - journals.physiology.org
As rapid progress in science and biotechnology is affecting the practice of renal medicine,
increasingly precise diagnostic assessment is needed to select the most effective …
increasingly precise diagnostic assessment is needed to select the most effective …
HybriSeq: Probe-based Device-free Single-cell RNA Profiling
D Foyt, D Brown, S Zhou, B Huang - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
We have developed the HybriSeq method for single-cell RNA profiling, which utilizes in situ
hybridization of multiple probes for targeted transcripts, followed by split-pool barcoding and …
hybridization of multiple probes for targeted transcripts, followed by split-pool barcoding and …
[PDF][PDF] Optimized RT-qPCR Assays for Rapid and Reliable Detection of SARS
J King, S Whitmore, C Drayton - 2023 - researchgate.net
Authors: Jiam King, Samuel Whitmore, Charlotte Drayton Abstract: The rise of SARS-CoV-2
has created an urgent need for accurate diagnostic tools to control the spread of COVID-19 …
has created an urgent need for accurate diagnostic tools to control the spread of COVID-19 …