Over the past few decades, the number of available structural bioinformatics pipelines,
libraries, plugins, web resources and software has increased exponentially and become …

Oxidative cyclizations are important transformations that occur widely during natural product
biosynthesis. The transformations from acyclic precursors to cyclized products can afford …

Review covering up to mid-2021 The structure of polyketide and non-ribosomal peptide
natural products is strongly influenced by how they are released from their biosynthetic …

One of the hallmark advances in our understanding of metalloprotein function is showcased
in our ability to design new, non-native, catalytically active protein scaffolds. This review …

Abstract The Diels–Alder reaction is one of the most powerful and widely used methods in
synthetic chemistry for the stereospecific construction of carbon–carbon bonds. Despite the …

Biocatalysis has undergone a tremendous development in the past few years. A plethora of
methods enable the rather rapid tailored-design of an enzyme for a targeted reaction such …

The Diels–Alder (DA) reaction is a cornerstone of synthesis, yet Nature does not use
catalysts for intermolecular [4+ 2] cycloadditions. Attempts to create artificial “Diels …

New enzyme catalysts are usually engineered by repurposing the active sites of natural
proteins. Here we show that design and directed evolution can be used to transform a non …

The calculation of accurate reaction energies and barrier heights is essential in
computational studies of reaction mechanisms and thermochemistry. To assess methods …

[4+ 2]-Cycloadditions are increasingly being recognized in the biosynthetic pathways of
many structurally complex natural products. A relatively small collection of enzymes from …