Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …
Controlling and enhancing CRISPR systems
Many bacterial and archaeal organisms use clustered regularly interspaced short
palindromic repeats–CRISPR associated (CRISPR–Cas) systems to defend themselves …
palindromic repeats–CRISPR associated (CRISPR–Cas) systems to defend themselves …
CRISPR-Cas13 inhibitors block RNA editing in bacteria and mammalian cells
P Lin, S Qin, Q Pu, Z Wang, Q Wu, P Gao, J Schettler… - Molecular cell, 2020 - cell.com
Cas13 has demonstrated unique and broad utility in RNA editing, nucleic acid detection,
and disease diagnosis; however, a constantly active Cas enzyme may induce unwanted …
and disease diagnosis; however, a constantly active Cas enzyme may induce unwanted …
CRISPR-cas3 of Salmonella Upregulates Bacterial Biofilm Formation and Virulence to Host Cells by Targeting Quorum-Sensing Systems
L Cui, X Wang, D Huang, Y Zhao, J Feng, Q Lu, Q Pu… - Pathogens, 2020 - mdpi.com
Salmonella is recognized as one of the most common microbial pathogens worldwide. The
bacterium contains the clustered regularly interspaced short palindromic repeats (CRISPR) …
bacterium contains the clustered regularly interspaced short palindromic repeats (CRISPR) …
Hfq-licensed RNA–RNA interactome in Pseudomonas aeruginosa reveals a keystone sRNA
The RNA chaperone Hfq plays important regulatory roles in many bacteria by facilitating the
base pairing between small RNAs (sRNAs) and their cognate mRNA targets. In the gram …
base pairing between small RNAs (sRNAs) and their cognate mRNA targets. In the gram …
Gene autoregulation by 3'UTR-derived bacterial small RNAs
Negative feedback regulation, that is the ability of a gene to repress its own synthesis, is the
most abundant regulatory motif known to biology. Frequently reported for transcriptional …
most abundant regulatory motif known to biology. Frequently reported for transcriptional …
The core and accessory Hfq interactomes across Pseudomonas aeruginosa lineages
The major RNA-binding protein Hfq interacts with mRNAs, either alone or together with
regulatory small noncoding RNAs (sRNAs), affecting mRNA translation and degradation in …
regulatory small noncoding RNAs (sRNAs), affecting mRNA translation and degradation in …
Specific and Global RNA Regulators in Pseudomonas aeruginosa
P Pusic, E Sonnleitner, U Bläsi - International Journal of Molecular …, 2021 - mdpi.com
Pseudomonas aeruginosa (Pae) is an opportunistic pathogen showing a high intrinsic
resistance to a wide variety of antibiotics. It causes nosocomial infections that are particularly …
resistance to a wide variety of antibiotics. It causes nosocomial infections that are particularly …
A type III-Dv CRISPR-Cas system is controlled by the transcription factor RpaB and interacts with the DEAD-box RNA helicase CrhR
How CRISPR-Cas systems defend bacteria and archaea against invading genetic elements
is well understood, but less is known about their regulation. In the cyanobacterium …
is well understood, but less is known about their regulation. In the cyanobacterium …
Regulatory interplay between small RNAs and transcription termination factor Rho
The largest and best studied group of regulatory small RNAs (sRNAs) in bacteria act by
modulating translation or turnover of messenger RNAs (mRNAs) through base-pairing …
modulating translation or turnover of messenger RNAs (mRNAs) through base-pairing …