The quest for treatment-free remission (TFR) and deep molecular response (DMR) in
chronic myeloid leukemia (CML) has been profoundly impacted by tyrosine kinase inhibitors …

Podosomes are highly dynamic, actin-rich adhesion structures of monocyte-derived cells,
certain transformed fibroblasts and carcinoma cells and have recently also been discovered …

The production of exosomes by tumor cells has been implicated in tumor-associated
immune suppression. In this study, we show that, in mice, exosomes produced by TS/A …

Aging represents a state of paradox where chronic inflammation is associated with declining
immune responses. Dendritic cells (DCs) are the major APCs responsible for initiating an …

Tumours have at least two mechanisms that can alter dendritic cell (DC) maturation and
function. The first affects the ability of haematopoietic progenitors to differentiate into …

There is growing evidence that activation of the immune system may be an effective
treatment for patients with either small cell lung cancer or non–small cell lung cancer …

2080 two forms of dot-like matrix contact that differ from those described above structurally
and functionally (reviewed in Linder and Aepfelbacher, 2003; Buccione et al., 2004) …

Chronic myeloid leukemia (CML) is a hematological cancer, characterized by a reciprocal
chromosomal translocation between chromosomes 9 and 22 [t (9; 22)], producing the Bcr …

The ABL tyrosine kinase inhibitor imatinib mesylate is highly effective in the treatment of
CML and is increasingly used in the stem cell transplantation (SCT) setting. Since ABL …

Immunotherapy for the treatment of metastatic melanoma remains a major clinical challenge.
The melanoma microenvironment may lead to local T cell tolerance in part through …