In eukaryotic cells AMP-activated protein kinase (AMPK) plays a major role in regulating
cellular energy balance. AMPK responds to changes in intracellular adenine nucleotide …

The AMP-activated protein kinase (AMPK) is a central regulator of multiple metabolic
pathways and may have therapeutic importance for treating obesity, insulin resistance, type …

Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions.
AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning …

Mammalian skeletal muscle comprises different fiber types, whose identity is first established
during embryonic development by intrinsic myogenic control mechanisms and is later …

Domestication of wild boar (Sus scrofa) and subsequent selection have resulted in dramatic
phenotypic changes in domestic pigs for a number of traits, including behavior, body …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

New therapeutic approaches to counter the increasing prevalence of obesity and type 2
diabetes mellitus are in high demand. Deregulation of the phosphoinositide-3-kinase …

Skeletal muscle plays an important role in regulating whole-body energy expenditure given
it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally …

White adipose tissue (WAT) plays an important role in the integration of whole-body
metabolism by storing fat and mobilizing triacylglycerol when needed. The released free …

During fasting and after exercise, skeletal muscle efficiently switches from carbohydrate to
lipid as the main energy source to preserve glycogen stores and blood glucose levels for …