Structure–activity relationships for ruthenium and osmium anticancer agents–towards clinical development

SM Meier-Menches, C Gerner, W Berger… - Chemical Society …, 2018 - pubs.rsc.org
Anticancer metallodrugs based on ruthenium and osmium are among the most investigated
and advanced non-platinum metallodrugs. Inorganic drug discovery with these agents has …

Hybrid organic− inorganic polyoxometalate compounds: from structural diversity to applications

A Dolbecq, E Dumas, CR Mayer, P Mialane - Chemical reviews, 2010 - ACS Publications
Polyoxometalates (POMs) are discrete anionic metaloxygen clusters which can be regarded
as soluble oxide fragments. They exhibit a great diversity of sizes, nuclearities, and shapes …

Organic dye-sensitized tandem photoelectrochemical cell for light driven total water splitting

F Li, K Fan, B Xu, E Gabrielsson, Q Daniel… - Journal of the …, 2015 - ACS Publications
Light driven water splitting was achieved by a tandem dye-sensitized photoelectrochemical
cell with two photoactive electrodes. The photoanode is constituted by an organic dye L0 as …

Ruthenium metallopharmaceuticals

MJ Clarke - Coordination Chemistry Reviews, 2002 - Elsevier
The well-developed synthetic chemistry of ruthenium, particularly with ammine, amine and
imine ligands, provides for many approaches to innovative new metallopharmaceuticals …

Arene ruthenium complexes as anticancer agents

G Süss-Fink - Dalton Transactions, 2010 - pubs.rsc.org
Neutral or cationic arene ruthenium complexes providing both hydrophilic as well as
hydrophobic properties due to the robustness of the ruthenium–arene unit hold a high …

The emergence of sulfoxides as efficient ligands in transition metal catalysis

G Sipos, EE Drinkel, R Dorta - Chemical Society Reviews, 2015 - pubs.rsc.org
Sulfoxides are capable of forming stable complexes with transition metals and there have
been many comprehensive studies into their binding properties. However, the use of …

[PDF][PDF] Non-platinum chemotherapeutic metallopharmaceuticals

MJ Clarke, F Zhu, DR Frasca - Chemical Reviews, 1999 - academia.edu
Despite the resounding success of cisplatin and closely related platinum antitumor agents, 1-
3 the movement of other transition-metal antitumor agents toward the clinic has been …

Recent developments in ruthenium anticancer drugs

A Levina, A Mitra, PA Lay - Metallomics, 2009 - academic.oup.com
Interest in Ru anticancer drugs has been growing rapidly since NAMI-A ((ImH+)[RuIIICl4
(Im)(S-dmso)], where Im= imidazole and S-dmso= S-bound dimethylsulfoxide) or KP1019 …

Trans-effects in octahedral transition metal complexes

BJ Coe, SJ Glenwright - Coordination Chemistry Reviews, 2000 - Elsevier
An extensive survey of the occurrences and origins of both structural trans-effects (STEs)
and kinetic trans-effects (KTEs) in octahedral d-transition metal complexes is presented. This …

Classical and non‐classical ruthenium‐based anticancer drugs: Towards targeted chemotherapy

W Han Ang, PJ Dyson - European Journal of Inorganic …, 2006 - Wiley Online Library
Ruthenium‐based anticancer chemotherapies are making significant advances in clinical
trials. Until recently, the focus has been on coordination complexes, and mechanisms such …