Transient receptor potential (TRP) channels are multifunctional signalling molecules with
many roles in sensory perception and cellular physiology. Therefore, it is not surprising that …

Hypertension affects two-thirds of people aged> 60 years and significantly increases the risk
of both vascular cognitive impairment and Alzheimer's disease. Hypertension compromises …

Increasing evidence from epidemiological, clinical and experimental studies indicate that
age-related cerebromicrovascular dysfunction and microcirculatory damage play critical …

The importance of (micro) vascular contributions to cognitive impairment and dementia
(VCID) in aging cannot be overemphasized, and the pathogenesis and prevention of age …

Chemotherapy‐induced cognitive impairment (“chemobrain”) is a frequent side‐effect in
cancer survivors treated with paclitaxel (PTX). The mechanisms responsible for PTX …

Adjustment of cerebral blood flow (CBF) to neuronal activity via neurovascular coupling
(NVC) has an essential role in maintenance of healthy cognitive function. In aging increased …

Aging-induced structural and functional alterations of the neurovascular unit lead to
impairment of neurovascular coupling responses, dysregulation of cerebral blood flow, and …

Cognitive impairment and dementia are major medical, social, and economic public health
issues worldwide with significant implications for life quality in older adults. The leading …

The process of aging includes changes in cellular biology that affect local interactions
between cells and their environments and eventually propagate to systemic levels. In the …

The mechanisms of neurovascular coupling contribute to ensuring brain energy supply is
sufficient to meet demand. Despite significant research interest, the mechanisms underlying …