Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer
WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
[HTML][HTML] DNA methylation-based diagnostic, prognostic, and predictive biomarkers in colorectal cancer
DNA methylation is an epigenetic mechanism regulating gene expression. Changes in DNA
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …
methylation were suggested to be useful biomarkers for diagnosis, and for the determination …
Novel diagnostic biomarkers in colorectal cancer
AL Zygulska, P Pierzchalski - International journal of molecular sciences, 2022 - mdpi.com
Colorectal cancer (CRC) is still a leading cause of cancer death worldwide. Less than half of
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …
cases are diagnosed when the cancer is locally advanced. CRC is a heterogenous disease …
DNA methylation profiles in cancer diagnosis and therapeutics
Y Pan, G Liu, F Zhou, B Su, Y Li - Clinical and experimental medicine, 2018 - Springer
Cancer initiation and proliferation is regulated by both epigenetic and genetic events with
epigenetic modifications being increasingly identified as important targets for cancer …
epigenetic modifications being increasingly identified as important targets for cancer …
DNA methylation-based testing in liquid biopsies as detection and prognostic biomarkers for the four major cancer types
Lung, breast, colorectal, and prostate cancers are the most incident worldwide. Optimal
population-based cancer screening methods remain an unmet need, since cancer detection …
population-based cancer screening methods remain an unmet need, since cancer detection …
DNA methylation biomarkers: cancer and beyond
Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …
or disease can be identified or monitored. They can reflect past environmental exposures …
[HTML][HTML] Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer
F Coppedè, A Lopomo, R Spisni… - World journal of …, 2014 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most common cancer worldwide and results from the
accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to …
accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to …
Validation of a Real-Time PCR–Based Qualitative Assay for the Detection of Methylated SEPT9 DNA in Human Plasma
NT Potter, P Hurban, MN White, KD Whitlock… - Clinical …, 2014 - academic.oup.com
BACKGROUND Epi proColon® is a new blood-based colorectal cancer (CRC) screening
test designed to determine the methylation status of a promoter region of the SEPT9 (septin …
test designed to determine the methylation status of a promoter region of the SEPT9 (septin …
Non-invasive colorectal cancer screening: an overview
Background: Colorectal cancer (CRC) follows a protracted stepwise progression, from
benign adenomas to malignant adenocarcinomas. If detected early, 90% of deaths are …
benign adenomas to malignant adenocarcinomas. If detected early, 90% of deaths are …
Systematic review of blood diagnostic markers in colorectal cancer
The purpose of this systematic review was to compare the diagnostic ability of blood markers
for colorectal cancer (CRC). A systematic review of the literature for diagnostic blood …
for colorectal cancer (CRC). A systematic review of the literature for diagnostic blood …