Glioblastoma is the most aggressive and the most common primary malignant brain tumor in
adults. Risk factors for glioblastoma are widely elusive and the clinical course is generally …

Standard treatment of primary and metastatic brain tumours includes high-dose
megavoltage-range radiation to the cranial vault. About half of patients survive> 6 months …

Oligodendrocytes wrap nerve fibres in the central nervous system with layers of specialized
cell membrane to form myelin sheaths. Myelin is destroyed by the immune system in multiple …

Simple Summary Glioblastoma is among the most lethal cancers in humans. Glioblastomas
exhibit a striking heterogeneity, which is maintained by a highly plastic, adaptable …

Astrocytes participate in all essential CNS functions, including blood flow regulation, energy
metabolism, ion and water homeostasis, immune defence, neurotransmission, and adult …

Cancer cell of origin is difficult to identify by analyzing cells within terminal stage tumors,
whose identity could be concealed by the acquired plasticity. Thus, an ideal approach to …

Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are
the end product of a cell lineage which has to undergo a complex and precisely timed …

Remyelination involves reinvesting demyelinated axons with new myelin sheaths. In stark
contrast to the situation that follows loss of neurons or axonal damage, remyelination in the …

Progressive phases of multiple sclerosis are associated with inhibited differentiation of the
progenitor cell population that generates the mature oligodendrocytes required for …

After central nervous system (CNS) demyelination—such as occurs during multiple sclerosis—
there is often spontaneous regeneration of myelin sheaths, mainly by oligodendrocytes but …