Rho family small GTPases serve as molecular switches involved in the regulation of diverse
cellular functions including various cytoskeleton-related events and gene transcription. The …

Diacylglycerol (DAG) has unique functions as a basic component of membranes, an
intermediate in lipid metabolism and a key element in lipid-mediated signaling. In …

Diacylglycerol is an essential second messenger in mammalian cells. The most prominent
intracellular targets of diacylglycerol and of the functionally analogous phorbol esters belong …

C1 domains, cysteine-rich modules originally identified in protein kinase C (PKC) isozymes,
are present in multiple signaling families, including PKDs, chimaerins, RasGRPs …

Reviews of signal transduction have often focused on the cascades of protein kinases and
protein phosphatases and their cytoplasmic substrates that become activated in response to …

Rac GTPases, small G-proteins widely implicated in tumorigenesis and metastasis,
transduce signals from tyrosine-kinase, G-protein-coupled receptors (GPCRs), and integrins …

The secretory pathway is of vital importance for eukaryotic cells and has a pivotal role in the
synthesis, sorting, processing and secretion of a large variety of bioactive molecules …

For many years protein kinase C (PKC) has been the subject of extensive studies as a
molecular target for the treatment of cancer and other diseases. To better define the role of …

Diacylglycerol (DAG) signaling relies on the presence of conserved domain 1 (C1) in its
target proteins. Phospholipase C–dependent generation of DAG after T cell receptor (TCR) …

Diacylglycerol is an essential second messenger in mammalian cells. The most prominent
intracellular targets of diacylglycerol and the functionally analogous phorbol esters belong to …