A Multiform Heterogeneity Framework for Alzheimer's Disease Based on Multimodal Neuroimaging
Understanding the heterogeneity of Alzheimer's disease (AD) is crucial for advancing
precision medicine specifically tailored to this disorder. Recent research has deepened our …
precision medicine specifically tailored to this disorder. Recent research has deepened our …
Investigation of patterns and associations of neuroinflammation in cognitive impairment
R Gan, H **e, Z Zhao, X Wu, R Wang, B Wu… - Cerebral …, 2025 - academic.oup.com
Neuroinflammation has been identified as an important pathological component of cognitive
impairment, and translocator protein imaging has become a valuable tool for assessing its …
impairment, and translocator protein imaging has become a valuable tool for assessing its …
The heterogeneity of Alzheimer's disease
M Husain - Brain, 2024 - academic.oup.com
Several years ago, when being interviewed for a grant, I found myself defending the claim
that Alzheimer's disease (AD) is a heterogeneous condition, that it consists of subtypes, and …
that Alzheimer's disease (AD) is a heterogeneous condition, that it consists of subtypes, and …
Reduced expression of fMRI subsequent memory effects with increasing severity across the Alzheimer's disease risk spectrum
In functional magnetic resonance imaging (fMRI) studies, episodic memory is commonly
investigated with the subsequent memory paradigm in which brain activity is recorded …
investigated with the subsequent memory paradigm in which brain activity is recorded …
A large-scale multi-centre study characterising atrophy heterogeneity in Alzheimer's disease
V Venkatraghavan, D Archetti, P Bourgeat, C Jiang… - medRxiv, 2024 - medrxiv.org
Background Previous studies reported on the existence of atrophy-based Alzheimer's
disease (AD) subtypes that associate with distinct clinical symptoms. However, the …
disease (AD) subtypes that associate with distinct clinical symptoms. However, the …
Data-driven brain atrophy staging in spinocerebellar ataxia type 3
Abstract Spinocerebellar ataxia type 3 (SCA3) is the most common autosomal dominant
ataxia worldwide. First targeted gene therapy trials have started, offering the intriguing …
ataxia worldwide. First targeted gene therapy trials have started, offering the intriguing …