Androgenic insensitivity syndrome is the most common cause of disorders of sexual
differentiation in 46, XY individuals. It results from alterations in the androgen receptor gene …

Differences/disorders of sex development (DSD) are a heterogeneous group of congenital
conditions that result in discordance between an individual's sex chromosomes, gonads …

Human sexual determination is initiated by a cascade of genes that lead to the development
of the fetal gonad. Whereas development of the female external genitalia does not require …

Disorders of sex development (DSD) are a heterogeneous group of pathologies that result in
an alteration in sex determination or differentiation. DSD are estimated to affect 1: 4,500 …

Background: Prenatal deficit of androgens or androgen action results in atypical genitalia in
individuals with XY disorders of sex development (XY, DSD). XY, DSD include mainly …

Certain patients with disorders of sex development (DSD), who bear Y chromosome material
in their karyotype, are at increased risk for the development of type II germ cell tumors (GCT) …

Complete androgen insensitivity syndrome (CAIS) is an X-linked recessive genetic disorder
resulting from maternally inherited or de novo mutations involving the androgen receptor …

Abstract Introduction Disorders of Sex Development (DSD) are a wide range of congenital
conditions characterized by an incongruence of components involved in sexual …

Abstract 17β-hydroxysteroid dehydrogenase 3 deficiency consists of a defect in the last
phase of steroidogenesis, in which androstenedione is converted into testosterone and …

Male development in mammals is normally initiated by the Y-linked gene Sry, which
activates expression of Sox9, leading to a cascade of gene activity required for testis …