Mechanical regulation of myofibroblast phenoconversion and collagen contraction
Activated fibroblasts promote physiological wound repair following tissue injury. However,
dysregulation of fibroblast activation contributes to the development of fibrosis by enhanced …
dysregulation of fibroblast activation contributes to the development of fibrosis by enhanced …
[HTML][HTML] The cytoplasmic actins in the regulation of endothelial cell function
VB Dugina, GS Shagieva, AS Shakhov… - International Journal of …, 2021 - mdpi.com
The primary function of the endothelial cells (EC) lining the inner surface of all vessels is to
regulate permeability of vascular walls and to control exchange between circulating blood …
regulate permeability of vascular walls and to control exchange between circulating blood …
Expression of α-smooth muscle actin determines the fate of mesenchymal stromal cells
Pro-fibrotic microenvironments of scars and tumors characterized by increased stiffness
stimulate mesenchymal stromal cells (MSCs) to express α-smooth muscle actin (α-SMA). We …
stimulate mesenchymal stromal cells (MSCs) to express α-smooth muscle actin (α-SMA). We …
YAP circular RNA, circYap, attenuates cardiac fibrosis via binding with tropomyosin-4 and gamma-actin decreasing actin polymerization
Cardiac fibrosis is a common pathological feature of cardiac hypertrophy. This study was
designed to investigate a novel function of Yes-associated protein (YAP) circular RNA …
designed to investigate a novel function of Yes-associated protein (YAP) circular RNA …
Cytosolic actin isoforms form networks with different rheological properties that indicate specific biological function
The implications of the existence of different actins expressed in epithelial cells for network
mechanics and dynamics is investigated by microrheology and confocal imaging. γ-actin …
mechanics and dynamics is investigated by microrheology and confocal imaging. γ-actin …
SMIFH2 has effects on Formins and p53 that perturb the cell cytoskeleton
Formin proteins are key regulators of the cytoskeleton involved in developmental and
homeostatic programs and human disease. For these reasons, small molecules interfering …
homeostatic programs and human disease. For these reasons, small molecules interfering …
[HTML][HTML] The Role of non-muscle actin paralogs in cell cycle progression and proliferation
E Jeruzalska, AJ Mazur - European Journal of Cell Biology, 2023 - Elsevier
Uncontrolled cell proliferation leads to several pathologies, including cancer. Thus, this
process must be tightly regulated. The cell cycle accounts for cell proliferation, and its …
process must be tightly regulated. The cell cycle accounts for cell proliferation, and its …
Unique and redundant functions of cytoplasmic actins and nonmuscle myosin II isoforms at epithelial junctions
The integrity and functions of epithelial barriers depend on the formation of adherens
junctions (AJs) and tight junctions (TJs). A characteristic feature of AJs and TJs is their …
junctions (AJs) and tight junctions (TJs). A characteristic feature of AJs and TJs is their …
Tumor promotion by γ and suppression by β non-muscle actin isoforms
Here we have shown that β-cytoplasmic actin acts as a tumor suppressor, inhibiting cell
growth and invasion in vitro and tumor growth in vivo. In contrast, γ-cytoplasmic actin …
growth and invasion in vitro and tumor growth in vivo. In contrast, γ-cytoplasmic actin …
Mammalian actins: isoform-specific functions and diseases
C Ampe, M Van Troys - The actin cytoskeleton, 2017 - Springer
Actin is the central building block of the actin cytoskeleton, a highly regulated filamentous
network enabling dynamic processes of cells and simultaneously providing structure …
network enabling dynamic processes of cells and simultaneously providing structure …