Psychedelics are a unique class of drug that commonly produce vivid hallucinations as well
as profound psychological and mystical experiences. A grou** of interconnected brain …

This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time
perception and ego dissolution, produces rapid and persistent therapeutic effects in human …

Psychedelics have attracted medical interest, but their effects on human brain function are
incompletely understood. In a comprehensive, within-subjects, placebo-controlled design …

Human brain organoids replicate much of the cellular diversity and developmental anatomy
of the human brain. However, the physiology of neuronal circuits within organoids remains …

Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …

This paper formulates the action of psychedelics by integrating the free-energy principle and
entropic brain hypothesis. We call this formulation relaxed beliefs under psychedelics …

No contemporary unifying framework has been provided for the study of non-ordinary states
of consciousness (NSCs) despite increased interest in hypnosis, meditation, and …

The use of low sub-perceptual doses of psychedelics (“microdosing”) has gained popularity
in recent years. Although anecdotal reports claim multiple benefits associated with this …

Brain function is a product of the balance between excitatory and inhibitory (E/I) brain
activity. Variation in the regulation of this activity is thought to give rise to normal variation in …