Resolution of chronic inflammatory disease: universal and tissue-specific concepts

G Schett, MF Neurath - Nature communications, 2018 - nature.com
Inflammation and its resolution is under-studied in medicine despite being essential for
understanding the development of chronic inflammatory disease. In this review article, we …

Signaling pathways in inflammation and anti-inflammatory therapies

YT Yeung, F Aziz, A Guerrero-Castilla… - Current …, 2018 - ingentaconnect.com
During the past decade, an abundance of new evidence highlighted the importance of
inflammation in the development of chronic pathologies such as neurodegeneration, cancer …

COVID‐19: Proposing a Ketone‐Based Metabolic Therapy as a Treatment to Blunt the Cytokine Storm

PC Bradshaw, WA Seeds, AC Miller… - Oxidative Medicine …, 2020 - Wiley Online Library
Human SARS‐CoV‐2 infection is characterized by a high mortality rate due to some patients
develo** a large innate immune response associated with a cytokine storm and acute …

Up-regulation of FOXO1 and reduced inflammation by β-hydroxybutyric acid are essential diet restriction benefits against liver injury

T Miyauchi, Y Uchida, K Kadono… - Proceedings of the …, 2019 - National Acad Sciences
Liver ischemia and reperfusion injury (IRI) is a major challenge in liver surgery. Diet
restriction reduces liver damage by increasing stress resistance; however, the underlying …

Tissue immunometabolism: development, physiology, and pathobiology

K Man, VI Kutyavin, A Chawla - Cell metabolism, 2017 - cell.com
Evolution of metazoans resulted in the specialization of cellular and tissue function. This was
accomplished by division of labor, which allowed tissue parenchymal cells to prioritize their …

Transcription factor Foxo1 is essential for IL-9 induction in T helper cells

S Malik, S Sadhu, S Elesela, RP Pandey… - Nature …, 2017 - nature.com
Abstract Interleukin 9 (IL-9)-producing helper T (Th9) cells have a crucial function in allergic
inflammation, autoimmunity, immunity to extracellular pathogens and anti-tumor immune …

Laminaria japonica Polysaccharide Suppresses Atherosclerosis via Regulating Autophagy-Mediated Macrophage Polarization

XY Li, YJ Wang, S Chen, LH Pan, QM Li… - Journal of Agricultural …, 2022 - ACS Publications
The present work aimed to explore the effect and underlying mechanism of a homogeneous
Laminaria japonica polysaccharide (LJP61A) on macrophage polarization in high-fat-diet …

Alveolar macrophages in allergic asthma: the forgotten cell awakes

C Draijer, M Peters-Golden - Current allergy and asthma reports, 2017 - Springer
Abstract Purpose of Review The role of alveolar macrophages in innate immune responses
has long been appreciated. Here, we review recent studies evaluating the participation of …

Exosomes from mmu_circ_0001359-modified ADSCs attenuate airway remodeling by enhancing FoxO1 signaling-mediated M2-like macrophage activation

Y Shang, Y Sun, J Xu, X Ge, Z Hu, J **ao, Y Ning… - … Therapy-Nucleic Acids, 2020 - cell.com
Asthma is the most common chronic disease and is characterized by airway remodeling and
chronic inflammation. Increasingly, studies have found that the activation and M1 phenotypic …

Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6 …

Y Wang, J Zhu, L Zhang, Z Zhang, L He, Y Mou… - Journal of Allergy and …, 2017 - Elsevier
Background C/EBP homologous protein (Chop), a marker of endoplasmic reticulum (ER)
stress, exhibits aberrant expression patterns during asthma development. However, its exact …