Neurochemical regulation of the expression and function of glial fibrillary acidic protein in astrocytes

D Li, X Liu, T Liu, H Liu, L Tong, S Jia, YF Wang - Glia, 2020 - Wiley Online Library
Glial fibrillary acidic protein (GFAP), a type III intermediate filament, is a marker of mature
astrocytes. The expression of GFAP gene is regulated by many transcription factors (TFs) …

Astroglia in Alzheimer's disease

A Verkhratsky, V Parpura… - Neuroglia in …, 2019 - Springer
Alzheimer's disease is the most common cause of dementia. Cellular changes in the brains
of the patients suffering from Alzheimer's disease occur well in advance of the clinical …

Exposure to mixtures of metals and neurodevelopmental outcomes: a multidisciplinary review using an adverse outcome pathway framework

K von Stackelberg, E Guzy, T Chu, BC Henn - Risk Analysis, 2015 - Wiley Online Library
Current risk assessment guidance calls for an individual chemical‐by‐chemical approach
that fails to capture potential interactive effects of exposure to environmental mixtures and …

Mitochondrion: a sensitive target for Pb exposure

Q Han, W Zhang, JC Guo, Q Zhu, H Chen… - The Journal of …, 2021 - jstage.jst.go.jp
Pb exposure is a worldwide environmental contamination issue which has been of concern
to more and more people. Exposure to environmental Pb and its compounds through food …

[HTML][HTML] Amelioration of cholesterol sulfate for lead-induced CTX cell apoptosis based on BDNF signaling pathway mediated cholesterol metabolism

SS Wang, X Xu, AX Lu, W Li, J Liu, C Liu… - … and Environmental Safety, 2022 - Elsevier
Lead (Pb), as a deleterious heavy metal, ubiquitously exists in environment and industry,
which engenders multi-organ disfunction, especially the brain of infants who are vulnerable …

Joint action toxicity of arsenic (As) and lead (Pb) mixtures in develo** zebrafish

K Kiper, JL Freeman - Biomolecules, 2022 - mdpi.com
Arsenic (As) and lead (Pb) are environmental pollutants found in common sites and linked to
similar adverse health effects. Multiple studies have investigated the toxicity of each metal …

Dietary fiber ameliorates lead‐induced gut microbiota disturbance and alleviates neuroinflammation

M Yao, X Shao, Y Wei, X Zhang… - Journal of the Science …, 2022 - Wiley Online Library
Dietary fiber (DF) is a carbohydrate from the edible part of plants and has the functions of
promoting gastrointestinal motility, regulating gut microbiota (GM) and improving health …

A comprehensive review of arsenic-induced neurotoxicity: Exploring the role of glial cell pathways and mechanisms

A Garg, S Bandyopadhyay - Chemosphere, 2025 - Elsevier
The review aims to examine the neurotoxic effects of arsenic, particularly exploring the roles
of glial cells-astrocytes, microglia, and oligodendrocytes, amid its widespread environmental …

Differential response to lead toxicity in rat primary microglia and astrocytes

J Peng, F Zhou, Y Wang, Y Xu, H Zhang, F Zou… - Toxicology and Applied …, 2019 - Elsevier
Lead (Pb) is one of the most widely studied occupational and environmental toxins. Chronic
exposure to Pb affects neural function in the central nervous system (CNS). Glial cells in the …

CDK5-induced p-PPARγ (Ser 112) downregulates GFAP via PPREs in develo** rat brain: effect of metal mixture and troglitazone in astrocytes

A Rai, S Tripathi, R Kushwaha, P Singh… - Cell death & …, 2014 - nature.com
The peroxisome proliferator-activated receptor gamma (PPARγ), a group of ligand-activated
transcriptional factors, is expressed in glial fibrillary acidic protein (GFAP)-immunoreactive …