T cell migration, search strategies and mechanisms

MF Krummel, F Bartumeus, A Gérard - Nature Reviews Immunology, 2016 - nature.com
T cell migration is essential for T cell responses; it allows for the detection of cognate antigen
at the surface of antigen-presenting cells and for interactions with other cells involved in the …

Mechanisms and dynamics of T cell-mediated cytotoxicity in vivo

S Halle, O Halle, R Förster - Trends in immunology, 2017 - cell.com
Cytotoxic T lymphocytes (CTLs) are critical in the elimination of infected or malignant cells
and are emerging as a major therapeutic target. How CTLs recognize and kill harmful cells …

NF-κB dynamics in the language of immune cells

M Aqdas, MH Sung - Trends in immunology, 2023 - cell.com
Biological discovery has been driven by advances in throughput and resolution of analysis
technologies. They have also created an indelible bias for snapshot-based knowledge …

Dynamic Multiplex tissue imaging in inflammation research

S Uderhardt, G Neag… - Annual Review of …, 2024 - annualreviews.org
Inflammation is a highly dynamic process with immune cells that continuously interact with
each other and parenchymal components as they migrate through tissue. The dynamic …

Brain-on-a-chip model enables analysis of human neuronal differentiation and chemotaxis

O Kilic, D Pamies, E Lavell, P Schiapparelli, Y Feng… - Lab on a Chip, 2016 - pubs.rsc.org
Migration of neural progenitors in the complex tissue environment of the central nervous
system is not well understood. Progress in this area has the potential to drive breakthroughs …

New tools for immunologists: models of lymph node function from cells to tissues

T Ozulumba, AN Montalbine… - Frontiers in …, 2023 - frontiersin.org
The lymph node is a highly structured organ that mediates the body's adaptive immune
response to antigens and other foreign particles. Central to its function is the distinct spatial …

Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods

F Bayerl, DA Bejarano, G Bertacchi… - European Journal of …, 2023 - Wiley Online Library
This article is part of the Dendritic Cell Guidelines article series, which provides a collection
of state‐of‐the‐art protocols for the preparation, phenotype analysis by flow cytometry …

Inflammatory chemokines direct and restrict leukocyte migration within live tissues as glycan-bound gradients

M Sarris, JB Masson, D Maurin, LM Van der Aa… - Current Biology, 2012 - cell.com
Chemokines are essential in many cell migration processes, including the recruitment of
leukocytes to sites of infection [1–3]. In the latter context, chemokines promote leukocyte …

Detection of rare antigen-presenting cells through T cell-intrinsic meandering motility, mediated by Myo1g

A Gérard, G Patino-Lopez, P Beemiller, R Nambiar… - Cell, 2014 - cell.com
To mount an immune response, T lymphocytes must successfully search for foreign material
bound to the surface of antigen-presenting cells. How T cells optimize their chances of …