Understanding tick biology and its implications in anti-tick and transmission blocking vaccines against tick-borne pathogens
Ticks are obligate blood-feeding ectoparasites that transmit a wide variety of pathogens to
animals and humans in many parts of the world. Currently, tick control methods primarily rely …
animals and humans in many parts of the world. Currently, tick control methods primarily rely …
A fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles
Ticks are blood-feeding arthropods that require heme for their successful reproduction.
During feeding they also acquire pathogens that are subsequently transmitted to humans …
During feeding they also acquire pathogens that are subsequently transmitted to humans …
Activity of native tick kinins and peptidomimetics on the cognate target G protein‐coupled receptor from the cattle fever tick, Rhipicephalus microplus (Acari: Ixodidae)
C **ong, K Kaczmarek, J Zabrocki… - Pest Management …, 2020 - Wiley Online Library
BACKGROUND Kinins are multifunctional neuropeptides that regulate key insect
physiological processes such as diuresis, feeding, and ecdysis. However, the physiological …
physiological processes such as diuresis, feeding, and ecdysis. However, the physiological …
A random small molecule library screen identifies novel antagonists of the kinin receptor from the cattle fever tick, Rhipicephalus microplus (Acari: Ixodidae)
BACKGROUND The southern cattle tick, Rhipicephalus microplus, is a primary vector of the
deadly bovine disease babesiosis. Worldwide populations of ticks have developed …
deadly bovine disease babesiosis. Worldwide populations of ticks have developed …
Target‐based discovery of antagonists of the tick (Rhipicephalus microplus) kinin receptor identifies small molecules that inhibit midgut contractions
BM Henriques‐Santos, D Baker, N Zhou… - Pest Management …, 2024 - Wiley Online Library
Abstract BACKGROUND A GPCR (G protein‐coupled receptor) target‐based approach was
applied to identify antagonists of the arthropod‐specific tick kinin receptor. These small …
applied to identify antagonists of the arthropod‐specific tick kinin receptor. These small …
Comparative morphological and transcriptomic analyses reveal chemosensory genes in the poultry red mite, Dermanyssus gallinae
Detection of chemical cues via chemosensory receptor proteins are essential for most
animals, and underlies critical behaviors, including location and discrimination of food …
animals, and underlies critical behaviors, including location and discrimination of food …
Comparative morphological and transcriptomic analyses reveal novel chemosensory genes in the poultry red mite, Dermanyssus gallinae and knockdown by RNA …
Detection of chemical cues via chemosensory receptor proteins are essential for most
animals, and underlies critical behaviors, including location and discrimination of food …
animals, and underlies critical behaviors, including location and discrimination of food …
A" Dual-Addition" Calcium Fluorescence Assay for the High-Throughput Screening of Recombinant G Protein-Coupled Receptors
G protein-coupled receptors (GPCRs) represent the largest superfamily of receptors and are
the targets of numerous human drugs. High-throughput screening (HTS) of random small …
the targets of numerous human drugs. High-throughput screening (HTS) of random small …
Small molecule antagonists and agonists of arthropod kinin receptors for pest control
XTDZGXBTXBEZDN-UHFFFAOYSA-N 3-(difluoromethyl)-N-(9-isopropyl-1, 2, 3, 4-tetrahydro-
1, 4-methanonaphthalen-5-yl)-1-methylpyrazole-4-carboxamide Chemical compound CC …
1, 4-methanonaphthalen-5-yl)-1-methylpyrazole-4-carboxamide Chemical compound CC …
[CITATION][C] Activity of Peptide-Based and Small Molecule Ligands of the Kinin Receptor from Mosquito Aedes Aegypti and Tick Rhipicephalus Microplus Through …
C **ong - 2020