Transcription factors (TFs) influence cell fate by interpreting the regulatory DNA within a
genome. TFs recognize DNA in a specific manner; the mechanisms underlying this …

Human platelets arise as subcellular fragments of megakaryocytes in bone marrow. The
physiologic demand, presence of disease such as cancer, or drug effects can regulate the …

The discovery of the GATA binding protein (GATA factor) transcription factor family
revolutionized hematology. Studies of GATA proteins have yielded vital contributions to our …

Mammalian erythropoiesis yields a highly specialized cell type, the mature erythrocyte,
evolved to meet the organismal needs of increased oxygen-carrying capacity. To better …

ChIP-seq has become the primary method for identifying in vivo protein–DNA interactions on
a genome-wide scale, with nearly 800 publications involving the technique appearing in …

The surge of human genetic information, enabled by increasingly facile and economically
feasible genomic technologies, has accelerated discoveries on the relationship of germline …

Normal erythropoiesis requires the precise regulation of gene expression patterns, and
transcription cofactors play a vital role in this process. Deregulation of cofactors has …

Megakaryocytopoiesis involves the commitment of haematopoietic stem cells, proliferation
and terminal differentiation of megakaryocytic progenitors (MK‐p) and maturation of …

Transcriptional regulation of thousands of genes instructs complex morphogenetic and
molecular events for heart development. Cardiac transcription factors choreograph gene …

The development of complex organisms requires the formation of diverse cell types from
common stem and progenitor cells. GATA family transcriptional regulators and their …