Integrating the active process of hair cells with cochlear function

AJ Hudspeth - Nature Reviews Neuroscience, 2014 - nature.com
Uniquely among human senses, hearing is not simply a passive response to stimulation.
Our auditory system is instead enhanced by an active process in cochlear hair cells that …

The physics of hearing: fluid mechanics and the active process of the inner ear

T Reichenbach, AJ Hudspeth - Reports on Progress in Physics, 2014 - iopscience.iop.org
Most sounds of interest consist of complex, time-dependent admixtures of tones of diverse
frequencies and variable amplitudes. To detect and process these signals, the ear employs …

A critique of the critical cochlea: Hopf—a bifurcation—is better than none

AJ Hudspeth, F Jülicher… - Journal of …, 2010 - journals.physiology.org
The sense of hearing achieves its striking sensitivity, frequency selectivity, and dynamic
range through an active process mediated by the inner ear's mechanoreceptive hair cells …

Diverse mechanisms of sound frequency discrimination in the vertebrate cochlea

R Fettiplace - Trends in neurosciences, 2020 - cell.com
Discrimination of different sound frequencies is pivotal to recognizing and localizing friend
and foe. Here, I review the various hair cell-tuning mechanisms used among vertebrates …

Whistling while it works: spontaneous otoacoustic emissions and the cochlear amplifier

CA Shera - Journal of the Association for Research in …, 2022 - Springer
Perhaps the most striking evidence for active processes operating within the inner ears of
mammals and non-mammals alike is their ability to spontaneously produce sound. Predicted …

Modelling cochlear mechanics

G Ni, SJ Elliott, M Ayat, PD Teal - BioMed research international, 2014 - Wiley Online Library
The cochlea plays a crucial role in mammal hearing. The basic function of the cochlea is to
map sounds of different frequencies onto corresponding characteristic positions on the …

An active oscillator model describes the statistics of spontaneous otoacoustic emissions

F Fruth, F Jülicher, B Lindner - Biophysical journal, 2014 - cell.com
Even in the absence of external stimulation, the cochleas of most humans emit very faint
sounds below the threshold of hearing, sounds that are known as spontaneous otoacoustic …

A resonance approach to cochlear mechanics

A Bell - PloS one, 2012 - journals.plos.org
Background How does the cochlea analyse sound into its component frequencies? In the
1850s Helmholtz thought it occurred by resonance, whereas a century later Békésy's work …

Unloading outer hair cell bundles in vivo does not yield evidence of spontaneous oscillations in the mouse cochlea

PM Quiñones, SWF Meenderink, BE Applegate… - Hearing research, 2022 - Elsevier
Along with outer hair cell (OHC) somatic electromotility as the actuator of cochlear
amplification, active hair bundle motility may be a complementary mechanism in the …

Salient features of otoacoustic emissions are common across tetrapod groups and suggest shared properties of generation mechanisms

C Bergevin, GA Manley… - Proceedings of the …, 2015 - National Acad Sciences
Otoacoustic emissions (OAEs) are faint sounds generated by healthy inner ears that provide
a window into the study of auditory mechanics. All vertebrate classes exhibit OAEs to varying …