“Where, O death, is thy sting?” A brief review of apoptosis biology

AH Wyllie - Molecular neurobiology, 2010 - Springer
Apoptosis was a term introduced in 1972 to distinguish a mode of cell death with
characteristic morphology and apparently regulated, endogenously driven mechanisms. The …

Heterochromatin and the DNA damage response: the need to relax

KL Cann, G Dellaire - Biochemistry and cell biology, 2011 - cdnsciencepub.com
Higher order chromatin structure has an impact on all nuclear functions, including the DNA
damage response. Over the past several years, it has become increasingly clear that …

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

F Rodier, DP Muñoz, R Teachenor… - Journal of cell …, 2011 - journals.biologists.com
DNA damage can induce a tumor suppressive response termed cellular senescence.
Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and …

Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells

T Secher, A Samba-Louaka, E Oswald… - PloS one, 2013 - journals.plos.org
Cellular senescence is an irreversible state of proliferation arrest evoked by a myriad of
stresses including oncogene activation, telomere shortening/dysfunction and genotoxic …

New insights into the role of PML in tumour suppression

P Salomoni, BJ Ferguson, AH Wyllie, T Rich - Cell research, 2008 - nature.com
The PML gene is involved in the t (15; 17) translocation of acute promyelocytic leukaemia
(APL), which generates the oncogenic fusion protein PML (promyelocytic leukaemia protein) …

Nuclear organization in genome stability: SUMO connections

S Nagai, N Davoodi, SM Gasser - Cell research, 2011 - nature.com
Recent findings show that chromatin dynamics and nuclear organization are not only
important for gene regulation and DNA replication, but also for the maintenance of genome …

AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity

BJ Ferguson, C Alexander, SW Rossi, I Liiv… - Journal of Biological …, 2008 - jbc.org
Develo** T cells encounter peripheral self-antigens in the thymus in order to delete
autoreactive clones. It is now known that the autoimmune regulator protein (AIRE), which is …

Multimodal light microscopy approaches to reveal structural and functional properties of promyelocytic leukemia nuclear bodies

C Hoischen, S Monajembashi, K Weisshart… - Frontiers in …, 2018 - frontiersin.org
The promyelocytic leukemia (pml) gene product PML is a tumor suppressor localized mainly
in the nucleus of mammalian cells. In the cell nucleus, PML seeds the formation of …

The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair

MW Lambert - Experimental Biology and Medicine, 2019 - journals.sagepub.com
Three major proteins in the nucleoskeleton, lamins, actin, and spectrin, play essential roles
in maintenance of nuclear architecture and the integrity of the nuclear envelope, in …

PML nuclear body biogenesis, carcinogenesis, and targeted therapy

Y Li, X Ma, W Wu, Z Chen, G Meng - Trends in cancer, 2020 - cell.com
Targeted therapy has become increasingly important in cancer therapy. For example,
targeting the promyelocytic leukemia PML protein in leukemia has proved to be an effective …