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“Where, O death, is thy sting?” A brief review of apoptosis biology
AH Wyllie - Molecular neurobiology, 2010 - Springer
Apoptosis was a term introduced in 1972 to distinguish a mode of cell death with
characteristic morphology and apparently regulated, endogenously driven mechanisms. The …
characteristic morphology and apparently regulated, endogenously driven mechanisms. The …
Heterochromatin and the DNA damage response: the need to relax
KL Cann, G Dellaire - Biochemistry and cell biology, 2011 - cdnsciencepub.com
Higher order chromatin structure has an impact on all nuclear functions, including the DNA
damage response. Over the past several years, it has become increasingly clear that …
damage response. Over the past several years, it has become increasingly clear that …
DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
F Rodier, DP Muñoz, R Teachenor… - Journal of cell …, 2011 - journals.biologists.com
DNA damage can induce a tumor suppressive response termed cellular senescence.
Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and …
Damaged senescent cells permanently arrest growth, secrete inflammatory cytokines and …
Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells
Cellular senescence is an irreversible state of proliferation arrest evoked by a myriad of
stresses including oncogene activation, telomere shortening/dysfunction and genotoxic …
stresses including oncogene activation, telomere shortening/dysfunction and genotoxic …
New insights into the role of PML in tumour suppression
P Salomoni, BJ Ferguson, AH Wyllie, T Rich - Cell research, 2008 - nature.com
The PML gene is involved in the t (15; 17) translocation of acute promyelocytic leukaemia
(APL), which generates the oncogenic fusion protein PML (promyelocytic leukaemia protein) …
(APL), which generates the oncogenic fusion protein PML (promyelocytic leukaemia protein) …
Nuclear organization in genome stability: SUMO connections
Recent findings show that chromatin dynamics and nuclear organization are not only
important for gene regulation and DNA replication, but also for the maintenance of genome …
important for gene regulation and DNA replication, but also for the maintenance of genome …
AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity
BJ Ferguson, C Alexander, SW Rossi, I Liiv… - Journal of Biological …, 2008 - jbc.org
Develo** T cells encounter peripheral self-antigens in the thymus in order to delete
autoreactive clones. It is now known that the autoimmune regulator protein (AIRE), which is …
autoreactive clones. It is now known that the autoimmune regulator protein (AIRE), which is …
Multimodal light microscopy approaches to reveal structural and functional properties of promyelocytic leukemia nuclear bodies
C Hoischen, S Monajembashi, K Weisshart… - Frontiers in …, 2018 - frontiersin.org
The promyelocytic leukemia (pml) gene product PML is a tumor suppressor localized mainly
in the nucleus of mammalian cells. In the cell nucleus, PML seeds the formation of …
in the nucleus of mammalian cells. In the cell nucleus, PML seeds the formation of …
The functional importance of lamins, actin, myosin, spectrin and the LINC complex in DNA repair
MW Lambert - Experimental Biology and Medicine, 2019 - journals.sagepub.com
Three major proteins in the nucleoskeleton, lamins, actin, and spectrin, play essential roles
in maintenance of nuclear architecture and the integrity of the nuclear envelope, in …
in maintenance of nuclear architecture and the integrity of the nuclear envelope, in …
PML nuclear body biogenesis, carcinogenesis, and targeted therapy
Targeted therapy has become increasingly important in cancer therapy. For example,
targeting the promyelocytic leukemia PML protein in leukemia has proved to be an effective …
targeting the promyelocytic leukemia PML protein in leukemia has proved to be an effective …