Pathogenic mechanisms following ischemic stroke
Stroke is the second most common cause of death and the leading cause of disability
worldwide. Brain injury following stroke results from a complex series of pathophysiological …
worldwide. Brain injury following stroke results from a complex series of pathophysiological …
Pathophysiology of cerebral ischemia and brain trauma: similarities and differences
Current knowledge regarding the pathophysiology of cerebral ischemia and brain trauma
indicates that similar mechanisms contribute to loss of cellular integrity and tissue …
indicates that similar mechanisms contribute to loss of cellular integrity and tissue …
Effect of early sustained prophylactic hypothermia on neurologic outcomes among patients with severe traumatic brain injury: the POLAR randomized clinical trial
Importance After severe traumatic brain injury, induction of prophylactic hypothermia has
been suggested to be neuroprotective and improve long-term neurologic outcomes …
been suggested to be neuroprotective and improve long-term neurologic outcomes …
Induced hypothermia and fever control for prevention and treatment of neurological injuries
KH Polderman - The Lancet, 2008 - thelancet.com
Increasing evidence suggests that induction of mild hypothermia (32–35° C) in the first hours
after an ischaemic event can prevent or mitigate permanent injuries. This effect has been …
after an ischaemic event can prevent or mitigate permanent injuries. This effect has been …
Translational research in traumatic brain injury
D Laskowitz, G Grant - 2016 - books.google.com
Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …
contributing to nearly one-third of all injury related deaths in the United States and exacting …
From evidence to clinical practice: effective implementation of therapeutic hypothermia to improve patient outcome after cardiac arrest
M Oddo, MD Schaller, F Feihl, V Ribordy… - Critical care …, 2006 - journals.lww.com
Objectives: Therapeutic hypothermia has been recommended for postcardiac arrest coma
due to ventricular fibrillation. However, no studies have evaluated whether therapeutic …
due to ventricular fibrillation. However, no studies have evaluated whether therapeutic …
Comparison of cooling methods to induce and maintain normo-and hypothermia in intensive care unit patients: a prospective intervention study
CW Hoedemaekers, M Ezzahti, A Gerritsen… - Critical Care, 2007 - Springer
Background Temperature management is used with increased frequency as a tool to
mitigate neurological injury. Although frequently used, little is known about the optimal …
mitigate neurological injury. Although frequently used, little is known about the optimal …
Brain temperature: physiology and pathophysiology after brain injury
S Mrozek, F Vardon, T Geeraerts - … research and practice, 2012 - Wiley Online Library
The regulation of brain temperature is largely dependent on the metabolic activity of brain
tissue and remains complex. In intensive care clinical practice, the continuous monitoring of …
tissue and remains complex. In intensive care clinical practice, the continuous monitoring of …
Hypothermia in the trauma patient
BJ Tsuei, PA Kearney - Injury, 2004 - Elsevier
Hypothermia is a common finding in severely injured patients. Historically described as a
consequence of wartime casualties where cold exposure was common, this topic has …
consequence of wartime casualties where cold exposure was common, this topic has …
Therapeutic hypothermia for neuroprotection: history, mechanisms, risks, and clinical applications
LV Karnatovskaia, KE Wartenberg… - The …, 2014 - journals.sagepub.com
The earliest recorded application of therapeutic hypothermia in medicine spans about 5000
years; however, its use has become widespread since 2002, following the demonstration of …
years; however, its use has become widespread since 2002, following the demonstration of …