Proteins can exist in a trinity of structures: the ordered state, the molten globule, and the
random coil. The five following examples suggest that native protein structure can …

Male infertility is a complex condition with a strong genetic and epigenetic background. This
review discusses the importance of genetic and epigenetic factors in the pathophysiology of …

Publisher Summary This chapter discusses the structure and function of DNA. DNA occupies
a critical role in cells, because it is the source of all intrinsic genetic information. Chemically …

Acetylation of the N-terminal tails of the core histones directly facilitates the recognition by
TFlllA of the 5s RNA gene wlthin model chromatin templates. This effect is independent of a …

Protamines are the major nuclear sperm proteins. The human sperm nucleus contains two
types of protamine: protamine 1 (P1) encoded by a single-copy gene and the family of …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

Histone proteins play essential structural and functional roles in the transition between
active and inactive chromatin states. Although histones have a high degree of conservation …

Chromatin organization of eukaryotic promoters is increasingly recognized as an important
factor in the regulation of transcription in vivo. To determine the role of chromatin in HIV‐1 …

Publisher Summary This chapter discusses Bloch's classes Type 1 (“true” protamines) and
Type 2 (“stable” protamines), for which substantial molecular information is now available …

A homogeneous oligonucleosome complex was prepared by reconstitution of highly
hyperacetylated histone octamers onto a linear DNA template consisting of 12 tandemly …