Caspase-8: The double-edged sword

R Mandal, JC Barrón, I Kostova, S Becker… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Caspase-8 is a cysteine-aspartate specific protease that classically triggers the extrinsic
apoptotic pathway, in response to the activation of cell surface Death Receptors (DRs) like …

[HTML][HTML] CASP8-652 6N insertion/deletion polymorphism and overall cancer risk: evidence from 49 studies

J Cai, Q Ye, S Luo, Z Zhuang, K He, ZJ Zhuo, X Wan… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract The CASP8-652 6N insertion/deletion (I/D) polymorphism reduces expression of
caspase 8. We conducted a meta-analysis to clarify the relationship between this …

Association of caspase-8 genotypes with oral cancer risk in Taiwan

LC Shih, CW Tsai, KT Sun, HM Hsu, TC Shen, YT Tsai… - In Vivo, 2019 - iv.iiarjournals.org
Background/Aim: Recently, mounting evidence has shown that caspase-8 (CASP8)
rs3834129 (-652, 6N insertion/deletion) polymorphism may serve as a genetic biomarker for …

[HTML][HTML] Tumor necrosis factor-alpha promoter polymorphism 308 G/A is not significantly associated with esophageal cancer risk: a meta-analysis

M Luo, Y Yang, D Luo, L Liu, Y Zhang, F **ao, J Yang… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Many studies have investigated the association between Tumor necrosis factor-α-308 G> A
(rs1800629) and the risk of esophageal cancer. However, their results are inconsistent …

Association Between the Asp312Asn, Lys751Gln, and Arg156Arg Polymorphisms in XPD and the Risk of Prostate Cancer

W Fu, F **ao, R Zhang, J Li, D Zhao… - … in Cancer Research …, 2017 - journals.sagepub.com
Prostate cancer is the most common solid cancer and genetic factors play important roles in
its pathogenesis. XPD is one of the 8 core genes involved in the nucleotide excision repair …

Association of caspase-8 genotypes with bladder cancer risk

M Chen, YT Tsai, WS Chang, LC Shih… - Anticancer …, 2019 - ar.iiarjournals.org
Background/Aim: Rs3824129 is a functional six-nucleotide insertion (I)/deletion (D)
polymorphism in the promoter region of caspase 8, an essential apoptosis gene. We aimed …

Shorter GGN repeats in androgen receptor gene would not increase the risk of prostate cancer

J Li, F **ao, Y Zhang, A Lan, Q Song… - … in Cancer Research …, 2017 - journals.sagepub.com
The association between the polymorphic GGN repeat in androgen receptor gene and
prostate cancer susceptibility has been studied extensively. But the results of these …

Association of caspase-8 genotypes with the risk for nasopharyngeal carcinoma in Taiwan

LC Shih, CW Tsai, WS Chang, TC Shen… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: Accumulating evidence shows that caspase-8 (Cas-8) rs3834129
genotypes determine susceptibility to various cancers, but their association with …