The biochemical indicators of tumor microenvironment (TME) that are different from normal
tissues provide the possibility for constructing intelligent drug delivery systems (DDSs) …

Recent technological approaches in drug delivery have attracted scientist interest for
improving therapeutic index of medicines and drug compliance. One of the powerful …

Owing to the complex and still not fully understood physiological environment, the
development of traditional nanosized drug delivery systems is very challenging for precision …

The application of nanotechnology to medicine, usually termed nanomedicine, has given a
crucial impulse to the design of various drug-loaded nanocarriers driven by the aim to …

Multiple biological barriers must be considered in the design of nanomedicines, including
prolonged blood circulation, efficient accumulation at the target site, effective penetration …

Click chemistry has become one of the most powerful construction tools in the field of
organic chemistry, materials science, and polymer science, as it offers hassle-free platforms …

Background Colorectal cancer (CRC) is the third most prevalent type of cancer for incidence
and second for mortality worldwide. Late diagnosis and inconvenient and expensive current …

Matrix metalloproteinases (MMPs) are a class of endopeptidases that are dependent on zinc
and facilitate the degradation of extracellular matrix (ECM) proteins, thereby playing pivotal …

To achieve the promise of stimuli-responsive drug delivery systems for the treatment of
cancer, they should (1) avoid premature clearance;(2) accumulate in tumors and undergo …

Tumor microenvironment (TME)-responsive nanosystems represent a category of intelligent
nanomaterials for precise anticancer drug delivery. Herein, we report a smart size …