The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the
body plan and in the differentiation of multiple tissues and organs. EMT also contributes to …

Gene regulatory networks (GRNs) provide system level explanations of developmental and
physiological functions in the terms of the genomic regulatory code. Depending on their …

If we were to point out in a few words what characterises the phenomenon of life, we would
probably mention the amazing plasticity and robustness of living systems, the innumerable …

Biological processes are often dynamic, thus researchers must monitor their activity at
multiple time points. The most abundant source of information regarding such dynamic …

Over the past decade, advances in both molecular developmental biology and evolutionary
ecology have made possible a new understanding of organisms as dynamic systems …

Comparative developmental evidence indicates that reorganizations in developmental gene
regulatory networks (GRNs) underlie evolutionary changes in animal morphology, including …

Evolutionary change in animal morphology results from alteration of the functional
organization of the gene regulatory networks (GRNs) that control development of the body …

Embryonic stem cell (ESC) self-renewal efficiency is determined by the level of Nanog
expression. However, the mechanisms by which Nanog functions remain unclear, and in …

High-throughput technologies for DNA sequencing and for analyses of transcriptomes,
proteomes and metabolomes have provided the foundations for deciphering the structure …

To understand how transcription factors function, it is essential to determine the range of
genes that they each bind and regulate in vivo. Here I review evidence that most animal …