At present, strong requirements in orthopaedics are still to be met, both in bone and joint
substitution and in the repair and regeneration of bone defects. In this framework …

While small bone defects heal spontaneously, large bone defects need surgical intervention
for bone transplantation. Autologous bone grafts are the best and safest strategy for bone …

The exploration of stem and progenitor cells holds promise for advancing our understanding
of the biology of tissue repair and regeneration mechanisms after injury. This will also help …

Bone tissue engineering represents one of the most challenging emergent fields for
scientists and clinicians. Current failures of autografts and allografts in many pathological …

Background As an ideal new graft material, porous tantalum (pTa) has excellent mechanical
properties and corrosion resistance and has received increased attention in the biomedical …

Adipose-derived stem/stromal cells (ASCs), together with adipocytes, vascular endothelial
cells, and vascular smooth muscle cells, are contained in fat tissue. ASCs, like the human …

Stem cells are defined by their capacity of self-renewal and multilineage differentiation,
which make them uniquely situated to treat a broad spectrum of human diseases. Based on …

Osteoporosis is characterized by low bone mass and elevated structural deterioration of the
bone tissue, resulting in bone weakness with an increased risk of fracture. Considering …

This paper presents the results of a structured review of the literature concerning in vitro
molecular assessment of osseointegration at the level of cell-surface topography …

Development of tools to be used for in vivo bone tissue regeneration focuses on cellular
models and differentiation processes. In searching for all the optimal sources, adipose tissue …