Plasticity is a hallmark of cells of the myelomonocytic lineage. In response to innate
recognition or signals from lymphocyte subsets, mononuclear phagocytes undergo adaptive …

Mononuclear phagocyte plasticity includes the expression of functions related to the
resolution of inflammation, tissue repair and remodelling, particularly when these cells are …

Various forms of fibrosis, comprising tissue thickening and scarring, are involved in 40% of
deaths across the world. Since the discovery of scarless functional healing in fetuses prior to …

Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and
immune defense against pathogens, macrophages are being rediscovered as regulators of …

Senescence is a form of cell-cycle arrest linked to tumor suppression and aging. However, it
remains controversial and has not been documented in nonpathologic states. Here we …

Distinct tumor microenvironment forms in each progression step of cancer and has diverse
capacities to induce both adverse and beneficial consequences for tumorigenesis. It is now …

During development and throughout adult life, macrophages derived from hematopoietic
progenitors are seeded throughout the body, initially in the absence of inflammatory and …

Macrophages are cells of the innate immunity constituting the mononuclear phagocyte
system and endowed with remarkable different roles essential for defense mechanisms …

Acute kidney injury is an increasingly common complication of hospital admission and is
associated with high levels of morbidity and mortality. A hypotensive, septic, or toxic insult …

The failure to replace damaged body parts in adult mammals results from a muted growth
response and fibrotic scarring. Although infiltrating immune cells play a major role in …